麝香通心滴丸治疗慢性心力衰竭作用机制研究进展

Research progress in treatment of chronic heart failure with Shexiang Tongxin dropping pills

慢性心力衰竭作为各种心脏疾病的晚期阶段,具有住院率高、病死率高的特点,严重影响患者预后。气虚血瘀证是心力衰竭的常见证型,具有益气活血作用的麝香通心滴丸在治疗慢性心力衰竭方面具有积极作用。从临床和基础研究资料来看,麝香通心滴丸可通过抗炎、抑制心肌纤维化和减轻心肌缺血再灌注损伤等多种机制改善心力衰竭,是潜在的心力衰竭治疗药物。未来需要更多大规模随机对照试验,提供更坚实的证据支持。

As an advanced stage of various heart diseases,chronic heart failure has characteristics of high hospitalization and case fatality rate,which seriously affects prognosis of patients.Qixu Xueyu syndrome is a frequent witness of heart failure.Shexiang Tongxin dropping pills having beneficial Qi and blood activating effect on the treatment of heart failure.Reviewing clinical and basic research in this field,Shexiang Tongxin dropping pills may play a role in the treatment of heart failure through variety of mechanisms such as anti-inflammation,anti-myocardial fibrosis and reduction of ischemia-reperfusion injury,which is a potential drug foRthe treatment of heart failure.In the future,more randomized controlled trials with large samples are needed to provide more strong evidence foRclinical application of the drug in heart failure.