肿瘤相关中性粒细胞在胃癌发生发展和治疗中的研究进展

Research progress on tumor associated neutrophils in the occurrence,development,and treatment of gastric cancer

迄今为止,胃癌的发病机制尚未完全明了。研究表明,肿瘤微环境(TME)对于肿瘤的发生和发展至关重要。TME中的肿瘤相关中性粒细胞(TANs)参与肿瘤进展的所有阶段,包括肿瘤起始、转移和免疫抑制,其复杂的作用机制增加了治疗胃癌的困难。随着对TME的深入研究,特异的治疗措施有望成为胃癌治疗的新希望。本文通过近年来文献回顾,研究和总结TANs在胃癌发生和转移中所起的作用,并阐述未来免疫治疗的发展方向,以期为临床和科研提供参考。

So far,the pathogenesis of gastric cancer(GC)has not been fully understood.Research shows that tumor microenvironment(TME)is essential for the occurrence and development of tumors.Tumor associated neutrophils(TANs)in TME are involved in all stages of tumor progression,including tumor initiation,metastasis,and immunosuppression.Due to the complex mechanism of TANs,the treatment of GC faces great challenges.With in-depth research on TME,specific treatment measures are expected for clinical treatment of GC.This article intends to review the literature in recent years,study and summarize the role of TANs in the occurrence and metastasis of GC,and briefly describe the development direction of targeted therapy in the future,trying to provide reference for clinical and scientific research.