宫腔因素不孕患者生殖道菌落分布及其与不孕症相关性研究

A study on the distribution and correlation of reproductive tract bacterial in infertility patients caused by intrauterine factors and its correlation with infertility

目的:探讨宫腔因素致不孕患者生殖道菌落分布及其与不孕症的相关性。方法:选择2021年1月-2022年12月收治的宫腔因素不孕患者100例为观察组,另外选择同期健康女性100例为对照组,所有入选者均采集生殖道分泌物进行检测。比较两组菌群多样性、菌群密集度、pH值、优势菌、阴道清洁度情况;比较两组阴道分泌物微生物检出情况;比较两组白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平。结果:观察组菌群多样性Ⅲ~Ⅳ级、菌群密集度Ⅲ~Ⅳ级、pH值>4.5、其他优势菌、阴道清洁度Ⅲ~Ⅳ度检出率均高于对照组,差异有统计学意义(P<0.05)。观察组解脲支原体、沙眼衣原体检出率高于对照组,差异有统计学意义(P<0.05)。观察组IL-6和TNF-α水平均高于对照组,差异有统计学意义(P<0.05)。结论:生殖道菌群多样性、密集度以及炎症反应、解脲支原体、沙眼衣原体感染均与不孕症密切关系,可为临床诊断、治疗提供参考。

Objective:To explore the distribution and correlation of reproductive tract bacteria in infertility patients caused by intrauterine factors and its correlation with infertility.Methods:All 100 patients with intrauterine infertility admitted to hospital from January 2021 to December 2022 were selected as the observation group,and 100 healthy women in the same period were selected as the control group.All participants were collected for reproductive tract secretions for testing.The diversity,density,pH value,dominant bacteria,and vaginal cleanliness of the two groups of bacteri were caompared.The microbial detection of vaginal discharge was compared between the two groups,interleukin 6(IL-6)and tumor necrosis factor-α(TNF-α)between the two groupsHorizontal.Results:The observation group had higher levels of microbial diversityⅢ~Ⅳ,microbial densityⅢ~Ⅳ,pH>4.5,other dominant bacteria,and higher detection rates of vaginal cleanlinessⅢ~Ⅳthan the control group,with statistically significant differences(P<0.05).The detection rate of ureaplasma urealyticum and chlamydia trachomatis in the observation group was significantly higher than that in the control group(P<0.05).The levels of IL-6,TNF-αin observation group were all higher than those of the control group,with statistically significant differences(P<0.05).Conclusion:The diversity and density of reproductive tract flora,inflammatory reaction,ureaplasma urealyticum and chlamydia trachomatis infection are closely related to infertility,which can provide reference for clinical diagnosis and treatment.