血清降钙素原、凝血因子联合C-反应蛋白检验诊断肝硬化并发自发性细菌性腹膜炎的价值分析

Value of Serum Procalcitonin,Coagulation Factor Combined with C reactive Protein in the Diagnosis of Liver Cirrhosis Complicated with Spontaneous Bacterial Peritonitis

目的评价以血清降钙素原、C反应蛋白、凝血因子共同检测肝硬化并自发性细菌性腹膜炎的临床效果。方法选取2022年6月—2023年6月单县中心医院收治的80例肝硬化患者为研究对象,40例并发腹膜炎为研究组,40例未并发腹膜炎为对照组,择同期健康体检人群40名为健康组,分析3组血清降钙素原,凝血因子、C-反应蛋白差异。结果研究组降钙素原(1.38±0.89)ng/mL、C反应蛋白(13.95±5.88)mg/L高于对照组和健康组、凝血因子Ⅱ、Ⅴ、Ⅷ分别为(30.25±4.68)%、(32.65±5.55)%、(190.41±14.36)%均低于对照组和健康组,差异有统计学意义(F=1.321、4.652、16.322、12.410、10.369,P均<0.05)。结论3项联合检查对肝硬化并发自发性细菌性腹膜炎诊断有较高的准确性,可在临床使用。

Objective To evaluate the clinical effect of serum procalcitonin,C-reactive protein and coagulation factor in the detection of liver cirrhosis with spontaneous bacterial peritonitis.Methods A total of 80 patients with cirrhosis admitted to Shanxian County Central Hospital from June 2022 to June 2023 were selected as the study subjects,40 pa⁃tients with peritonitis were selected as the study group,40 patients without peritonitis were selected as the control group,and 40 healthy people were selected as the healthy group during the same period.The differences of serum pro⁃calcitonin,coagulation factor and C-reactive protein among the three groups were analyzed.Results In study group,procalcitonin(1.38±0.89)ng/mL,C-reactive protein(13.95±5.88)mg/L are higher than those in control group and healthy group,coagulation factorⅡ,ⅤandⅧare lower than those in control group and healthy group,respectively(30.25±4.68)%,(32.65±5.55)%and(190.41±14.36)%,the differences were statistically significant(F=1.321,4.652,16.322,12.410,10.369,all P<0.05).Conclusion The three combined tests have high accuracy in the diagnosis of cir⁃rhosis complicated with spontaneous bacterial peritonitis and can be used in clinic.