甲状腺乳头状癌cN0患者颈侧区淋巴结转移发生的影响因素分析

Analysis of Influencing Factors on the Occurrence of Lymph Node Metas⁃tasis in the Lateral Cervical Region in Patients with Papillary Thyroid Car⁃cinoma cN0

目的探讨与调查甲状腺乳头状癌cN0患者颈侧区淋巴结转移发生的因素。方法回顾性选取2020年2月—2023年1月江苏省连云港市第一人民医院诊治的96例甲状腺乳头状癌cN0患者的临床资料,根据淋巴是否发生结转移分为转移组(n=16)和非转移组(n=80)。对其影响因素进行分析。结果经单因素分析显示,转移组的肿瘤直径、临床分期、吸烟、饮酒与非转移组对比,差异有统计学意义(P均<0.05)。经Logistic多因素回归分析显示肿瘤直径、临床分期、吸烟、饮酒为导致颈侧区淋巴结转移发生的危险因素(OR=2.103、1.785、3.276、4.924,P均<0.05)。结论甲状腺乳头状癌cN0患者颈侧区淋巴结转移依然比较常见,肿瘤直径、临床分期、吸烟、饮酒为导致颈侧区淋巴结转移发生的独立危险因素,需要临床予以重视,及时防止淋巴结发生转移。

Objective To explore and investigate the factors of the occurrence of lymph node metastasis in the lateral cervical region of patients with papillary thyroid carcinoma cN0.Methods.The chinical data of 96 patients with cN0 of papillary thyroid carcinoma diagnosed and treated in the Lianyungang First People's Hospital,Jiangsu Province from February 2020 to January 2023 were retrospectively selected.According to whether lymph node metastasis oc⁃curred,they were divided into metastatic group(n=16)and non-metastatic group(n=80).The influencing factors are analyzed.Results Univariate analysis showed that the tumor diameter,clinical stage,smoking and drinking in the metastatic group were significantly different from those in the non-metastatic group and the differences were statisti⁃cally significant(all P<0.05).Multivariate Logistic regression analysis showed that tumor diameter,clinical stage,smoking and drinking were the risk factors for cervical lymph node metastasis(OR=2.103,1.785,3.276,4.924,all P<0.05).Conclusion Cervical lymph node metastasis is still common in patients with thyroid papillary carcinoma cN0.Tumor diameter,clinical stage,smoking and drinking are independent risk factors leading to cervical lymph node me⁃tastasis,which need clinical attention to prevent lymph node metastasis in time.