卡前列素氨丁三醇联合宫腔球囊压迫宫腔治疗产后出血的效果分析

Analysis of the Effect of Carboprost Tromethamine Combined with Uter⁃ine Cavity Balloon Compression of the Uterine Cavity in the Treatment of Postpartum Hemorrhage

目的探讨在产后出血治疗中应用卡前列素氨丁三醇联合宫腔球囊压迫宫腔治疗方法,对于有效控制病情、提高产妇安全性的作用效果。方法回顾性分析2020年3月—2023年6月灌南县第一人民医院产科收治的40例产后出血产妇的临床资料,根据治疗方法不同分组,将前期仅使用卡前列素氨丁三醇止血的患者作为参照组(20例),将经前列素氨丁三醇止血后再采取宫腔球囊压迫宫腔治疗的患者作为联合组(20例),对比两组宫缩功能指标、救治和复苏情况、并发症发生率。结果联合组产妇子宫肌自发性及缝合术后的收缩频率、收缩活动力、收缩幅度高于参照组,差异有统计学意义(P均<0.05)。联合组止血时间、24 h出血量、复苏时间均优于参照组,差异有统计学意义(P均<0.05)。联合组子宫正常复旧率为95.00%,高于参照组的70.00%,差异有统计学意义(χ2=4.329,P=0.037)。联合组和参照组均未发生子宫肌层坏死、宫腔积脓、子宫破裂、子宫切除、体温过低、心脏负荷过重和产褥感染等并发症。结论在产后出血的治疗方案开展中,卡前列素氨丁三醇联合宫腔球囊压迫宫腔治疗具有安全、有效、操作简单、止血迅速等优点,显著降低了缝合术后并发症的发生率。

Objective To explore the effect of application of carboprost tromethamine combined with uterine cavity balloon compression of the uterine cavity in the treatment of postpartum hemorrhage on the effective control of the con⁃dition and the improvement of maternal safety.Methods The clinical data of 40 cases of postpartum hemorrhage moth⁃ers admitted to the Department of Obstetrics of Guannan County First People's Hospital from March 2020 to June 2023 were retrospectively analyzed.They were grouped according to different treatment methods,the patients only us⁃ing carboprost tromethamine to stop hemorrhage in the early stage was taken as the reference group(20 cases).The pa⁃tients with treatment of uterine cavity balloon compression of the uterine cavity after trans-carboprost tromethamine hemostasis was taken as the combined group(20 cases).The indicators of uterine contraction function,rescue and re⁃suscitation,and complication rate were obtained in the reference group and the combined group.Results The fre⁃quency,activity and amplitude of spontaneous and sutured contraction of uterine muscle in combination group were higher than those in reference group,and the differences were statistically significant(all P<0.05).The hemostatic time,24 hours blood loss and resuscitation time of the combined group were better than those of the reference group,and the differences were statistically significant(all P<0.05).The normal uterine relapse rate in the combination group was 95.00%,higher than that in the reference group(70.00%),and the difference was statistically significant(χ2=4.329,P=0.037).No complications such as myometriosis,pyometria,uterine rupture,hysterectomy,hypothermia,car⁃diac overload and puerperal infection occurred in both the combination group and the reference group.Conclusion In the development of treatment protocols for postpartum hemorrhage,carboprost tromethamine combined with uterine balloon compression of the uterine cavity has the advantages of safety,effectiveness,simplicity of operation,rapid he⁃mostasis,and significantly reduces the incidence of post-suture complications.