分析三联、四联药物方案治疗胃溃疡的临床效果

Clinical Effect of Triple and Quadruple Drug Regimens in the Treatment of Gastric Ulcer

目的探讨胃溃疡患者选择四联药物治疗后的临床效果。方法选取2022年1月—2023年8月广东药科大学附属第一医院收治的76例胃溃疡患者为研究对象,依据投掷硬币法分组,参照组(38例)选择三联药物治疗,研究组(38例)选择四联药物治疗,比较两组治疗总有效率、胃灼痛评分、胃溃疡面积、上腹疼痛评分、临床症状改善时间。结果研究组治疗总有效率为97.37%,明显高于参照组,差异有统计学意义(χ2=6.176,P<0.05)。治疗后,研究组胃灼痛评分、胃溃疡面积、上腹疼痛评分、临床症状改善时间均低于参照组,差异有统计学意义(P均<0.05)。结论同三联药物比较,胃溃疡患者接受四联药物治疗,可显著提升临床效果,有效改善疾病症状,可促进胃溃疡患者的良好预后。

Objective To investigate the clinical effect of quadruple drug therapy in patients with gastric ulcer.Methods Seventy-six patients with gastric ulcer admitted to the First Affiliated Hospital of Guangdong Pharmaceuti⁃cal University from January 2022 to August 2023 were selected as the research object and divided into groups ac⁃cording to coin tossing method.The reference group(38 cases)received triple drug therapy,and the study group(38 cases)received quadruple drug therapy.The total effective rate,the score of heartburn pain,the area of gastric ulcer,the score of upper abdominal pain and the improvement time of clinical symptoms were compared between the two groups.Results The total effective rate of the study group was 97.37%,which was significantly higher than that of the reference group,and the difference was statistically significant(χ2=6.176,P<0.05).After treatment,the score of heartburn pain,the area of gastric ulcer,the score of upper abdominal pain and the improvement time of clinical symptoms in the study group were lower than those in the reference group,and the differences were statistically sig⁃nificant(all P<0.05).Conclusion Compared with triple drug,quadruple drug treatment for gastric ulcer patients can significantly improve the clinical effect,effectively improve the disease symptoms,and promote the good prognosis of patients with gastric ulcer.