氯吡格雷联合阿司匹林对轻中度急性脑梗死患者神经功能缺损及炎症反应的影响

Effect of clozapine combined with Aspirin on neurologic impairment and inflammatory response in patients with mild to moderate acute cerebral infarction

目的探讨氯吡格雷联合阿司匹林对轻中度急性脑梗死(ACI)患者神经功能缺损情况、炎症反应的影响,为改善患者临床效果提供依据。方法选择2019年6月至2020年6月山西省运城市临猗县中医医院就诊的150例轻中度ACI患者为研究对象,根据患者病情症状治疗,将其分为观察组(75例)、对照组(75例)。对照组口服阿司匹林肠溶片治疗,观察组在此基础上予以口服硫酸氢氯吡格雷片治疗,并进行随访观察。结果治疗后,观察组总有效率为93.3%,高于对照组的78.7%;观察组炎性因子同型半胱氨酸(Hcy)、基质金属蛋白酶-9(MMP-9)、超敏C反应蛋白(hs-CRP)降低幅度高于对照组,美国国立卫生院神经功能缺损评分(NIHSS)降低幅度也高于对照组评分,差异有统计学意义。结论氯吡格雷联合阿司匹林可有效抑制轻中度ACI患者炎症反应,改善其神经功能缺损情况,疗效显著。

Objective To investigate the effect of clopidogrel combined with aspirin on neurological impairment and inflammatory reaction in patients with mild to moderate ACI,and to provide evidence for improving clinical efficacy.Methods A total of 150 patients with mild to moderate ACI Linyi County Traditional Chinese Medicine Hospital from June 2019 to June 2020 were selected and randomly divided into observation group and control group.The control group was treated with aspirin enteric-coated tablets,and the observation group was treated with clopidogrel sulfate tablets on the basis of times.Results After treatment,the total effective rate of the observation group was 93.3%,which was higher than that of the control group(78.7%),and the decrease range of inflammatory factors Hcy,MMP-9,hs-CRP in the observation group was higher than that of the control group,and the decrease range of NIHSS score was also higher than that of the control group.Conclusion Clopidogrel and aspirin can effectively inhibit the inflammatory reaction of patients with mild to moderate acute cerebral infarction,and improve their neurological impairment,the efficacy is significant.