阿司匹林预防子痫前期的研究进展

Research progress of aspirin in preventing preeclampsia

阿司匹林是一种非甾体类抗炎药,通过非选择性且不可逆抑制环氧合酶(COX)起作用,抑制前列腺素和血栓素的产生,抑制血小板聚集;阿司匹林还通过抑制COX-1抑制缺氧诱导的可溶性fms样酪氨酸激酶-1过表达;增加滋养细胞的增殖和侵袭,抑制滋养细胞凋亡。子痫前期是一种复杂的多系统疾病,诊断标准为突发性高血压(妊娠>20周)和至少一个其他相关并发症,包括蛋白尿、母体器官功能障碍或子宫胎盘功能障碍。最新研究发现胎盘中许多长链非编码RNA(lncRNA)和微小RNA(miRNAs)的表达改变与子痫前期发生的病理生理过程有关,它参与了胎盘发育和母体免疫。本文就阿司匹林预防子痫前期的研究进展进行综述,以期为临床预防妊娠期高血压疾病提供参考。

Aspirin is a non-steroidal anti-inflammatory drug that acts by non-selective and irreversible inhibition of cyclooxygenase(COX),thereby suppressing the production of prostaglandins and thromboxanes and inhibiting platelet aggregation.Aspirin also inhibits hypoxia-induced overexpression of soluble fms-like tyrosine kinase-1 by inhibiting COX-1.Additionally,Aspirin enhances the proliferation and invasion while inhibiting apoptosis of trophoblasts.Preeclampsia is a complex multi-system disorder diagnosed by sudden onset hypertension(>20 weeks of gestation)and at least one other associated complication,including proteinuria,maternal organ dysfunction,or uteroplacental dysfunction.Recent studies have found that altered expression of many lncRNAs and miRNAs in the placenta is associated with the pathophysiological,which is involved in placental development and maternal immunity.In this article,we discuss the research progress of aspirin in the prevention of pre-eclampsia,aiming to providing a reference for the clinical prevention of gestational hypertension.