艾博韦泰治疗获得性免疫缺陷综合征的效果及药物不良反应

Effectiveness of albuvirtide in the treatment of acquired immunodeficiency syndrome and the influencing factors of adverse drug reactions

目的探讨艾博韦泰(ABT)治疗获得性免疫缺陷综合征(AIDS)患者的疗效及药物不良反应。方法选取2021年5月至2023年5月苏州市第五人民医院收治的AIDS患者92例纳入研究,分析其药物疗效及危险因素。结果92例患者基线HIV RNA为5.3(5.0,6.4)Log10 copies/ml,其中84例患者治疗40 d检测HIV RNA为2.4(1.0,3.9)Log10 copies/ml,与基线比较,降低了2.9 Log10 copies/ml,差异具有统计学意义(Z=0.872,P<0.05);其他8例患者HIV RNA>4.8 Log10 copies/ml。基线CD4+T计数为(358±176)个/μl,治疗40 d后CD4+T计数为(443±187)个/μl,CD4+T细胞计数均上升;AIDS患者17例发生不良反应,其中常见不良反应发生率为76%(13/17),重要不良反应发生率为24%(4/17);单因素分析结果显示吸烟、CD4+、CD8+、血红蛋白减少、白细胞减少、贫血、药物过敏史发生率可能影响不良反应的发生,差异具有统计学意义(P<0.05)。多因素分析显示,吸烟、白细胞减少、贫血、既往有过敏史是不良反应发生的独立危险因素。结论ABT治疗AIDS可降低HIV RNA的复制率,提高免疫功能,吸烟、白细胞减少、贫血、既往药物过敏是不良反应发生的独立危险因素。

Objective To explore the efficacy and adverse drug reactions of albuvirtide(ABT)in the treatment of patients with acquired immunodeficiency syndrome(AIDS).Methods A total of 92 patients with AIDS admitted to Suzhou Fifth People′s Hospital from May 2021 to May 2023 were selected.Drug efficacy and risk factors were analysed.Results The baseline HIV RNA of 92 patients was 5.3(5.0,6.4)Log10 copies/ml,of which the mean HIV RNA of 84 patients tested at 40 d of treatment was 2.4(1.0,3.9)Log10 copies/ml.Compared with the baseline,there was a decrease of 2.9 Log10 copies/ml,and difference was statistically significant(Z=0.872,P<0.05).The other 8 patients had HIV RNA>4.8 Log10 copies/ml.The baseline CD4+T-lymph count was(358±176)/μl,and after 40 d of treatment the CD4+T-lymph count was(443±187)/μl,and CD4+T-cell counts were all significantly increased.A total of 17 patients experienced adverse drug reactions,in which the incidence of common adverse reactions was 76%(13/17),important adverse reactions was 24%(4/17).The results of univariate analysis showed that smoking,CD4+,CD8+,decreased hemoglobin,decreased white blood cells,anemia,and a his-tory of drug allergy had a statistically significant impact on the occurrence of adverse reactions(P<0.05);and mul-tifactorial analysis showed that smoking,leukopenia,a history of drug allergy and anaemia were independent risk factors for distinguishing the occurrence of the occurrence of adverse reactions.Conclusion ABT for AIDS can reduce the replication rate of HIV RNA and improve the immune function,a history of drug allergy and smok-ing,leukopenia and anaemia are independent risk factors for adverse reactions.