沙库巴曲缬沙坦与培哚普利治疗急性心肌梗死经皮冠状动脉介入术后心力衰竭的疗效对比

Comparative efficacy of sacubitril valsartan and perindopril in post-AMI heart failure treatment after PCI

目的比较沙库巴曲缬沙坦以及培哚普利治疗急性心肌梗死(AMI)患者经皮冠状动脉介入治疗(PCI)术后心力衰竭的疗效。方法回顾性选取浙江省苍南县人民医院2021年1月至2022年6月收治的112例AMI患者,根据治疗情况分为沙库巴曲缬沙坦组和培哚普利组,2组患者均接受PCI及常规药物治疗,观察2组患者在治疗前后心功能变化情况以及不良事件发生率。结果与培哚普利组相比,沙库巴曲缬沙坦组N末端B型利钠肽前体(NT-proBNP)水平降低,差异有统计学意义(P<0.05),2组的血压控制水平差异无统计学意义(P>0.05),沙库巴曲缬沙坦组心率改善情况优于培哚普利组(P<0.05),2组均能有效改善患者的心功能,但较之培哚普利组,沙库巴曲缬沙坦组心功能改善情况更明显(P<0.05)。2组不良事件发生率差异无统计学意义(P>0.05)。结论在AMI患者行PCI后的心力衰竭治疗中,沙库巴曲缬沙坦可能是一种有效的药物选择。沙库巴曲缬沙坦在改善心功能不全、降低NT-proBNP水平以及稳定心率方面,可能更优于培哚普利。

Objective To compare the effectiveness of sacubitril valsartan and perindopril in the treat-ment of heart failure in patients with acute myocardial infarction(AMI)following percutaneous coronary interven-tion(PCI).Methods A total of 112 AMI patients admitted to Cangnan County People′s Hospital from January 2021 to June 2022 were selected,and were divided into the sacubitril valsartan group and the perindopril group based on their treatment outcomes.Both groups of patients received PCI and conventional drug treatment.The changes in cardiac function and incidence of adverse events before and after treatment were observed in both groups.Results Compared to the perindopril group,the N-terminal pro-B-type natriuretic peptide(NT-proBNP)levels was lower in sacubitril valsartan group.While there was no statistically significant difference in blood pres-sure control levels between the two groups.The heart rate improvement in the sacubitril valsartan group was better than that in the perindopril group(P<0.05).Both groups were able to effectively improve the cardiac function,but the sacubitril valsartan group showed more significant improvement(P<0.05).However,there was no statistically significant difference in the incidence of adverse events between two groups(P>0.05).Conclusion Sacubitril valsartan could be an effective medication choice in treating heart failure post-acute myocardial infarction and PCI.It seems to be superior to perindopril in improving cardiac function,reducing NT-proBNP levels,and stabiliz-ing heart rate.