组蛋白乳酸化修饰在恶性肿瘤中的研究进展

Research progress on histone lactylation in malignant tumors

组蛋白赖氨酸乳酸化修饰是2019年新发现的一种酰化修饰,在基因表达、细胞代谢以及疾病治疗等生物过程中发挥着重要作用。近年来,乳酸化修饰生化相关研究取得突破性进展,尤其是在乳酸化修饰的生理功能以及与疾病相关性等领域逐渐受到关注。本文简要介绍乳酸化修饰的鉴定、生物学功能及其在恶性肿瘤中的作用,这将为进一步探索乳酸化修饰的功能和机制提供理论基础。

Histone lysine lactylation(Kla)was identified as an emerging histone acylation in 2019.Recent studies suggest that Kla plays a significant role in gene expression,cell metabolism and disease therapy.Most researches concentrating on biochemistry of Kla has obtained considerable development,and the physiological functions of Kla and its relationship with disease begun to get attention in recent years.In this review,we briefly introduce the identification of Kla,Kla biological functions and its role in malignant tumor,which will provide a theoretical basis for further exploration of the functions and mechanisms of Kla.