阿托伐他汀联合曲美他嗪治疗老年冠心病的效果分析

Analysis on Effect of Atorvastatin Combined with Trimetazidine in Treatment of Elderly Coronary Heart Disease

目的:分析阿托伐他汀联合曲美他嗪治疗老年冠心病的效果。方法:选取2021年9月—2022年12月南通市紫琅医院内科收治的老年冠心病患者60例作为研究对象,依据随机数字表法分为两组,各30例。对照组采取曲美他嗪治疗,研究组在对照组基础上采用阿托伐他汀钙治疗。比较两组治疗效果。结果:治疗前,两组左心室舒张末期内径(LVDD)、左室射血分数(LVEF)、6 min步行距离比较,差异无统计学意义(P>0.05);治疗后,两组LVDD小于治疗前,且研究组小于对照组,两组LVEF高于治疗前,且研究组高于对照组,两组6 min步行距离大于治疗前,且研究组大于对照组,差异有统计学意义(P<0.05)。治疗前,两组心绞痛发作次数与心绞痛持续时间比较,差异无统计学意义(P>0.05);治疗后,两组心绞痛发作次数少于治疗前,且研究组少于对照组,两组心绞痛持续时间短于治疗前,且研究组短于对照组,差异有统计学意义(P<0.05)。治疗前,两组体力、病情及社会心理状况评分比较,差异无统计学意义(P>0.05);治疗后,两组体力、病情、社会心理状况评分高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05)。结论:阿托伐他汀联合曲美他嗪治疗老年冠心病的效果较好,可改善患者心功能、临床症状及生活质量。

Objective:To analyze the effect of atorvastatin combined with trimetazidine in the treatment of elderly coronary heart disease.Methods:From September 2021 to December 2022,60 elderly patients with coronary heart disease admitted to the Department of Internal Medicine of Nantong Zilang Hospital were selected as the study subjects.They were divided into two groups according to random number table method,with 30 cases in each group.The control group was treated with trimetazidine,and the study group was treated with atorvastatin on the basis of control group.The treatment effects were compared between the two groups.Results:Before treatment,there was no significant difference in left ventricular end-diastolic diameter(LVDD),left ventricular ejection fraction(LVEF)and 6-min walking distance between the two groups(P>0.05);After treatment,the LVDD in the two groups was lower than that before treatment,and the LVDD in the study group was lower than that in the control group;the LVEF in the two groups was higher than that before treatment,and the LVEF in the study group was higher than that in the control group;the 6-min walking distance in the two groups was longer than that before treatment,and this index in the study group was longer than that in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the number of angina pectoris attacks and the duration of angina pectoris between the two groups(P>0.05);After treatment,the number of angina pectoris attacks in the two groups was less than that before treatment,and this index in the study group was less than that in the control group,while the duration of angina pectoris in the two groups was shorter than that before treatment,and this index in the study group was shorter than that in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the scores of physical strength,disease condition and psychosocial status between the two groups(P>0.05);After treatment,the scores of physical strength,disease condition and psychosocial status in the two groups were higher than those before treatment,and the scores in the study group were higher than those in the control group,and the difference was statistically significant(P<0.05).Conclusion:The combination of atorvastatin and trimetazidine is effective in the treatment of elderly patients with coronary heart disease,and can improve the patient's cardiac function,clinical symptoms and quality of life.