3例伴基因重排及嗜酸性粒细胞增多的髓系/淋巴系肿瘤病例分析

Analysis of 3 Cases of Myeloid/lymphoid Tumors with Gene Rearrangement and Eosinophilia

伴成纤维生长因子受体1、血小板衍生生长因子受体基因重排或中心粒旁物质1-Janus激酶2及嗜酸性粒细胞增多的髓系/淋系肿瘤是2016年世界卫生组织淋巴造血系统肿瘤分类中的独立疾病类型,其共同特征是融合基因的形成导致酪氨酸激酶异常表达,临床中较为罕见。该文报告3例伴基因重排及嗜酸性粒细胞增多的髓系/淋巴细胞系肿瘤病例,分析其临床表现、相关检查结果,以期为临床诊断和治疗提供参考。

Myeloid/lymphoid tumors associated with fibroblast growth factor receptor 1,platelet-derived growth factor receptor gene rearrangement or paracentriolar substance 1-Janus kinase 2 and eosinophilia is an independent disease type in the 2016 World Health Organization classification of lymphohematopoietic system tumors,whose common feature is that the formation of fusion genes leads to abnormal expression of tyrosine kinases,which is relatively rare in clinical practice.This article reports three cases of myeloid/lymphoid tumors with gene rearrangements and eosinophilia,and analyzes their clinical manifestations and related examination results,with a view to providing a reference for clinical diagnosis and treatment.