血清甲状腺球蛋白检测在分化型甲状腺癌诊断及预后评估中的应用价值分析

Application Value of Serum Thyroglobulin Detection in Diagnosis and Prognosis Assessment of Differentiated Thyroid Carcinoma

目的:探讨血清甲状腺球蛋白检测在分化型甲状腺癌诊断及预后评估中的应用价值。方法:选取2022年8月—2023年8月徐州市矿山医院收治的分化型甲状腺癌患者60例作为观察组,选取同期甲状腺瘤患者60例作为甲状腺瘤组,选取同期体检健康者60例作为对照组。三组受试者均进行血清甲状腺球蛋白检测,观察组行甲状腺腺叶切除术以及术后放射性碘治疗。比较三组受试者血清甲状腺球蛋白水平与阳性率;比较观察组术前、术后7 d血清甲状腺球蛋白水平;观察组随访1年,根据患者淋巴结转移及远处转移情况,将观察组分为未发生转移组、淋巴结转移组、远处转移组,比较三组血清甲状腺球蛋白水平与阳性率。结果:三组血清甲状腺球蛋白水平比较,观察组>甲状腺瘤组>对照组,观察组血清甲状腺球蛋白阳性率高于甲状腺瘤组与对照组,差异有统计学意义(P<0.05);甲状腺瘤组血清甲状腺球蛋白阳性率与对照组比较,差异无统计学意义(P>0.05)。术后7 d,观察组血清甲状腺球蛋白水平低于术前,差异有统计学意义(P<0.05)。经随访发现,60例分化型甲状腺癌患者未发生转移17例,发生淋巴结转移28例,发生远处转移15例。三组血清甲状腺球蛋白水平与阳性率比较,远处转移组>淋巴结转移组>未发生转移组,差异有统计学意义(P<0.05)。结论:血清甲状腺球蛋白检测在分化型甲状腺癌诊断及预后中的应用价值较高,能够为临床鉴别甲状腺良恶性病变、评估预后提供可靠依据。

Objective:To investigate the application value of serum thyroglobulin detection in the diagnosis and prognosis assessment of differentiated thyroid carcinoma.Methods:Sixty patients with differentiated thyroid cancer admitted to Xuzhou Mining Hospital from August 2022 to August 2023 were selected as the observation group,sixty patients with thyroid tumor during the same period were selected as the thyroid tumor group,and sixty healthy subjects during the same period were selected as the control group.Serum thyroglobulin was detected in all three groups,and the observation group received thyrolobectomy and postoperative radioactive iodine therapy.Serum thyroglobulin levels and positive rates were compared among the three groups.The serum thyroglobulin levels of the observation group were compared before and 7 days after operation.The observation group was followed up for 1 year.According to the lymph node metastasis and distant metastasis of patients,the observation group was divided into no metastasis group,lymph node metastasis group and distant metastasis group.The serum thyroglobulin level and positive rate of the three groups were compared.Results:The serum thyroglobulin level of the three groups was compared,observation group>thyroid tumor group>control group,the positive rate of serum thyroglobulin in the observation group was higher than that in the thyroid tumor group and control group,the difference was statistically significant(P<0.05);There was no significant difference in the positive rate of serum thyroglobulin between the thyroid tumor group and the control group(P>0.05);On the 7th day after operation,the serum thyroglobulin level in the observation group was lower than before operation,and the difference was statistically significant(P<0.05);After follow-up,17 of the 60 patients with differentiated thyroid cancer did not develop metastasis,28 had lymph node metastasis,and 15 had distant metastasis;The serum thyroglobulin level and positive rate of the three groups were compared,distant metastasis group>lymph node metastasis group>no metastasis group,the difference was statistically significant(P<0.05).Conclusion:Serum thyroglobulin detection has a high value in the diagnosis and prognosis of differentiated thyroid carcinoma,which can provide a reliable basis for differentiating benign and malignant thyroid lesions and evaluating prognosis.