戊乙奎醚雾化吸入结合振动排痰机在脑出血术后肺部感染的应用效果

Effect of penehyclidine aerosol inhalation combined with vibration expectorator on patients with pulmonary infection after intracerebral hemorrhage

目的探究戊乙奎醚雾化吸入结合振动排痰机治疗对脑出血术后肺部感染患者谷胱甘肽过氧化物酶(GSH-Px)、总抗氧化能力(T-AOC)的影响。方法随机数表法将本院2021年1月至2022年12月就诊的130例脑出血术后肺部感染患者分为研究组(65例)与对照组(65例)。对照组接受常规治疗,研究组在此基础上行振动排痰机联合戊乙奎醚雾化吸入治疗。观察2组住院时间、机械通气时间、肺部音缓解时间及咳嗽缓解时间,并对2组排痰量及痰液性质、血气指标、炎性因子、GSH-Px、T-AOC进行治疗前、后对比。结果研究组住院时间、机械通气时间、肺部音缓解时间及咳嗽缓解时间比对照组短,差异有统计学意义(P<0.05)。2组治疗后24 h排痰量及痰液性质优于治疗前,且研究组优于对照组,差异有统计学意义(P<0.05)。2组治疗后血氧饱和度(SpO_(2))、动脉血氧分压(PaO_(2))比治疗前高,动脉血二氧化碳分压(PaCO_(2))比治疗前低,且研究组优于对照组,差异有统计学意义(P<0.05)。2组治疗后肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、白细胞介素1β(IL-1β)比治疗前低,且研究组低于对照组,差异有统计学意义(P<0.05)。2组治疗后GSH-Px、T-AOC比治疗前高,且研究组高于对照组,差异有统计学意义(P<0.05)。结论戊乙奎醚雾化吸入结合振动排痰机治疗可明显缩短脑出血术后肺部感染患者住院时间,调节机体血气指标,提升GSH-Px、T-AOC水平。

Objective To investigate the effect of penehyclidine aerosol inhalation combined with a vibration expectorator on glutathione peroxidase(GSH-Px)and total antioxidant capacity(T-AOC)in patients with pulmonary infection after intracerebral hemorrhage.Methods A random number table method was used to divide 130 postoperative pulmonary infection patients with cerebral hemorrhage who visited our hospital from January 2021 to December 2022 into a study group(n=65)and a control group(n=65).The control group received routine treatment,while the study group received a vibration sputum ejection machine combined with nebulized inhalation of penehyclidine for treatment on this basis.The hospitalization time,mechanical ventilation time,lung rale relief time,and cough relief time of the two groups were observed,and the sputum output,sputum properties,blood gas indicators,inflammatory factors,GSH-Px,and T-AOC before and after treatment between the two groups were compared.Results The hospitalization time,mechanical ventilation time,lung rale relief time,and cough relief time of the study group were shorter than those of the control group,and the differences were statistically significant(P<0.05).The sputum output and properties of the two groups after 24 hours of treatment were better than those before treatment,and the research group was better than the control group,the differences were statistically significant(P<0.05).After treatment,oxygen saturation and PaO_(2) in both groups were higher than those before treatment,and PaCO_(2) in arterial blood was lower than that before treatment,the study group was better than the control group,the differences were statistically significant(P<0.05).Tumor necrosis factorα(TNF-α),interleukin-1β(IL-1β),and IL-6 of the two groups after treatment were lower than that before treatment,and the study group was lower than those the control group,and the differences were statistically significant(P<0.05).After treatment,GSH-Px and T-AOC in both groups were higher than those before treatment,and those the study group were higher than the control group,the differences were statistically significant(P<0.05).Conclusion Penehyclide aerosol inhalation combined with a vibration expectorator can significantly shorten the hospital stay of patients with pulmonary infection after intracerebral hemorrhage,adjust the body blood gas index,and increase the level of GSH-Px and T-AOC.