氨磺必利联合度洛西汀治疗男性强制戒毒合并抑郁人员的临床疗效观察

Clinical Efficacy of Amsulpride Combined with Duloxetine in Treatment of Depression in Forced Detoxification Patients

目的:分析强制戒毒抑郁人员临床治疗中采取氨磺必利与度洛西汀联合方案的效果。方法:抽取2019年1月~2023年6月间南平司法强制隔离戒毒所收治的60例强制戒毒人员中合并抑郁患者,根据电脑随机数字表法进行分组,对照组30例予以度洛西汀治疗,观察组30例予以氨磺必利联合度洛西汀治疗,比较两组患者的临床疗效、疾病症状、神经递质水平与安全性。结果:治疗后,观察组患者的总有效率为96.67%,高于对照组的76.67%(P<0.05);观察组患者的稽延性戒断症状量表(protracted withdrawal symptom scale,PWS)评分为(8.80±2.13)分,汉密尔顿抑郁量表(hamilton depression scale-17,HAMD-17)评分为(14.02±2.03)分,分别低于对照组的(12.12±2.91)分与(16.17±2.11)分(P<0.05);观察组患者的5-羟色胺(5-hydroxytryptamine,5-HT)水平、γ-氨基丁酸(γ-aminobutyric acid,GABA)水平及多巴胺(dopamine,DA)水平均高于对照组(P<0.05);观察组中不良反应的发生率是20.00%,对照组为16.67%,组间比较,差异无统计学意义(P>0.05)。结论:氨磺必利联合度洛西汀治疗强制戒毒抑郁人员有助于患者的治疗效果升高,促进其疾病症状进一步缓解,改善神经递质各项指标,同时安全性高。

Objective:To analyze the effect of amisulpride combined with duloxetine in clinical treatment of depression in forced detoxification patients.Methods:6o cases of pa-tients with compulsory detoxification depression were admitted to our hospital from January 2019 to June 2023 were divided into groups according to the computer random number table method.30 cases of patients in the control group were treated with duloxetine,and 30 cases of patients in the observation group were treated with amsulpride combined with duloxe-tine.The clinical efficacy,disease symptoms,neurotransmitter levels and safety of the two groups were compared.Results:After treatment,in the observation group,the total effective rate was 96.67%,which was higher than 76.67%that in the control group(P<0.05).In the observation group,the PWS score and HAMD-17 score were(14.02±2.03)points and(10.02±2.63)points,which were lower than(12.12±2.91)points and(16.17±2.11)points those of control group,respectively(P<0.05).In the observation group,the levels of 5-HT,GABA and DA were higher than the control group(P<0.05).The incidence of adverse re-actions was 20.00%in the observation group and 16.67%in the control group,and there was no statistical significance between groups(P>0.05).Conclusion:The combination of amsulpride and duloxetine in the treatment of forced detoxification patients with depression can increase the therapeutic effect of patients,promote the further remission of their disease symptoms,improve the neurotransmitter indicators,and have high safety.