糠酸莫米松鼻喷雾剂治疗鼻窦炎伴鼻息肉患者的疗效及对其黏膜组织重塑的影响

Efficacy of Mometasone furoate nasal spray in the treatment of sinusitis with nasal polyps and its influence on mucosal tissue remodeling

目的:观察糠酸莫米松鼻喷雾剂治疗鼻窦炎伴鼻息肉(CRSwNP)患者的疗效及其对黏膜组织重塑的影响。方法:将2021年1月至2022年12月江西上饶市广信区人民医院收治的CRSwNP患者60例纳入研究,随机分为对照组(n=30)和观察组(n=30)。两组均接受鼻窦开放手术治疗。术后对照组给予常规抗生素治疗,观察组在此基础上加以糠酸莫米松鼻喷雾剂治疗。比较两组鼻腔粘膜上皮化时间、鼻腔通气恢复时间和住院时间,对黏膜组织重塑情况和鼻结膜炎生存质量量表(RQLQ)两者评分进行比较,并对两组疗效和术后复发率进行比较。结果:观察组鼻粘膜上皮化时间、鼻通气恢复时间、住院时间均低于对照组(P<0.05);治疗后,观察组黏膜组织重塑情况评分、RQLQ量表评分均低于对照组(P<0.05);观察组治疗总有效率高于对照组(96.67%vs 73.33%)(P<0.05),但复发率无统计学意义(P>0.05)。结论:运用糠酸莫米松鼻喷雾剂治疗CRSwNP患者,能提高疗效,促使鼻腔粘膜上皮化,提高患者的生活质量,具有较高的临床应用价值。

Objective:To observe the efficacy of Mometasone furoate nasal spray in the treatment of sinusitis with nasal polyps(CRSwNP)and its effect on mucosal remodeling.Methods:A total of 60 patients with CRSwNP admitted to Guangxin District People's Hospital of Shangrao City,Jiangxi Province from January 2021 to December 2022 were included in the study and randomly divided into control group(n=30)and observation group(n=30).Both groups received open sinus surgery.After operation,the control group was treated with conventional antibiotics,and the observation group was treated with mometasone furoate nasal spray.Nasal mucosal epithelialization time,nasal ventilation recovery time and hospital stay were compared between the two groups.Mucosal remodeling and nasal conjunctivitis Quality of Life scale(RQLQ)scores were compared,and the efficacy and postoperative recurrence rate were compared between the two groups.Results:The time of nasal epithelization,recovery time of nasal ventilation and hospitalization in observation group were lower than those in control group(P<0.05).After treatment,the scores of mucosal remodeling and RQLQ scale in observation group were lower than those in control group(P<0.05).The total effective rate of the observation group was higher than that of the control group(96.67%vs 73.33%)(P<0.05),but the recurrence rate had no statistical significance(P>0.05).Conclusion:The use of Mometasone furoate nasal spray in the treatment of CRSwNP patients can improve the curative effect,promote the epithelization of nasal mucosa,improve the quality of life of patients,and have high clinical application value.