清胰汤辅助治疗重症急性胰腺炎临床疗效及安全性观察

Clinical efficacy and safety of Qingyi Decoction in the adjuvant treatment of severe acute pancreatitis

目的:探究清胰汤辅助治疗重症急性胰腺炎患者的临床疗效及安全性。方法:选取2020年7月至2022年7月本院收治的重症急性胰腺炎患者76例作为研究对象。随机将患者分为研究组与对照组,每组各38例。对照组采取乌司他丁等治疗;研究组采取清胰汤辅助乌司他丁治疗,两组均治疗14 d后进行数据观察,对比两组的临床疗效、中医症候积分、胰腺功能改善时间、胃肠功能恢复情况及不良反应。结果:研究组的治疗总有效率显著高于对照组(P<0.05)。治疗前,两组的腹痛剧烈、胸闷腹胀、恶心呕吐及便溏不爽等中医症候积分均无显著差异。治疗后两组的中医症候积分均下降,且研究组的中医症候积分均显著低于对照组(P<0.05),研究组的尿淀粉酶恢复正常时间与血淀粉酶恢复正常时间均比对照组显著缩短(P<0.05)。研究组腹痛消失时间、发热消失时间、肠鸣音恢复时间与腹胀消失时间均比对照组显著缩短(P<0.05)。研究组不良反应率比对照组显著降低(P<0.05)。结论:清胰汤辅助治疗重症急性胰腺炎可提高疗效,改善临床症状,促进胰腺功能及胃肠功能恢复,减少不良反应。

Objective:To explore the clinical efficacy and safety of Qingyi Decoction in the adjuvant treatment of severe acute pancreatitis.Methods:76 patients with severe acute pancreatitis admitted to our hospital from July 2020 to July 2022 were selected as the study objects.The patients were randomly divided into study group and control group,38 cases in each group.The control group was treated with ulinastatin.The study group was treated with Qingyi Decoction supplemented with ulinastatin.The data of both groups were observed after 14 days of treatment,and the clinical efficacy,TCM symptom score,pancreatic function improvement time,gastrointestinal function recovery and adverse reactions of the two groups were compared.Results:The total effective rate of the study group was significantly higher than that of the control group(P<0.05).Before treatment,the scores of acute abdominal pain,chest tightness,abdominal distension,nausea,vomiting and loose stool were not significantly different between the two groups.After treatment,the scores of Chinese medicine symptoms in both groups decreased,and the scores of Chinese medicine symptoms in the study group were significantly lower than those in the control group(P<0.05),and the time of urine amylase return to normal and blood amylase return to normal in the study group were significantly shorter than those in the control group(P<0.05).The disappearance time of abdominal pain,fever,intestinal sound recovery time and abdominal distension in the study group were significantly shorter than those in the control group(P<0.05).The adverse reaction rate of the study group was significantly lower than that of the control group(P<0.05).Conclusion:Qingyi Decoction can improve the curative effect,improve the clinical symptoms,promote the recovery of pancreatic function and gastrointestinal function,and reduce the adverse reactions.