年龄对结核性胸膜炎患者抗结核治疗后血生化指标的影响

Impact of age on blood biochemical indicators in patients with tuberculous pleurisy after anti-tuberculosis treatment

目的:探究年龄对结核性胸膜炎患者抗结核治疗后血生化指标的影响。方法:选取本院2019年5月至2022年5月期间收治的142例结核性胸膜炎患者作为研究对象。根据世界卫生组织(World Health Organization,WHO)年龄划分标准将患者分为老年组(n=29,年龄>59岁)、中年组(n=40,44岁<年龄≤59岁)、青年组(n=73,年龄≤44岁)。三组均进行抗结核治疗,分析比较三组的治疗效果,实验室指标和血生化指标水平。结果:三组治疗效果比较差异无统计学意义。三组治疗前及治疗后的γ-干扰素(Interferon-γ,INF-γ)与结核分歧杆菌脱氧核苷酸(Mycobacterium tuberculosis DNA,TB-DNA)阳性率比较无统计学差异。三组治疗前血生化指标比较差异无统计学意义;治疗后,三组肌酐(Creatinine,Cr)、尿素氮(Blood urea nitrogen,BUN)、尿酸(Uric acid,UA)、总胆红素(Total bilirubin,TBIL)、总蛋白(Total Proteins,TP)、谷丙转氨酶(Alanine transaminase,ALT)比较差异有统计学意义;中年组Cr、TP水平低于老年组与青年组,老年组与中年组BUN、UA、TBIL、ALT水平高于青年组(P<0.05)。结论:结核性胸膜炎患者抗结核治疗后的血生化指标水平变化受年龄影响,对中老年患者较大。

Objective:To investigate the impact of age on blood biochemical indicators in patients with tuberculous pleurisy after anti-tuberculosis treatment.Methods:A total of 142 patients with tuberculous pleurisy admitted to our hospital from May 2019 to May 2022 were selected as the study subjects.According to the World Health Organization(WHO)age classification criteria,the patients are divided into elderly group(n=29,age>59 years),middle-aged group(n=40,44 years<age≤59 years)and young group(n=73,age≤44 years).All groups were given anti-tuberculosis treatment.Therapeutic effects,laboratory indicators and blood biochemical indicators in the three groups were comparatively analyzed.Results:There was no statistically significant difference in therapeutic effects,interferon-γ(INF-γ),or the positive rate of mycobacterium tuberculosis DNA(TB-DNA)among the three groups of pre and post treatment.There was no statistically significant difference in blood biochemical indicators among the three groups before treatment.After treatment,the differences in creatinine(Cr),blood urea nitrogen(BUN),uric acid(UA),total bilirubin(TBIL),total protein(TP)and alanine transaminase(ALT)were statistically significant.The levels of Cr and TP in the middle-aged group were lower than those in the elderly group and the young group.The levels of BUN,UA,TBIL and ALT in elderly and middle-aged groups were lower than those in the young group(P<0.05).Conclusion:The changes in blood biochemical indicators in patients with tuberculous pleurisy after anti-tuberculosis treatment are influenced by age,and the impact on middle-aged and elderly patients is greater than young patients.