肝纤四项联合血小板检测在肝纤维化诊断中的应用价值

Application value of liver fibre-four combined platelet tests in the diagnosis of liver fibrosis

目的:探讨肝纤维化诊断中肝纤四项联合血小板检测的应用价值。方法:选取本院2021年11月至2023年6月期间收治的疑似肝纤维化患者80例作为研究对象,纳入研究组。另选取同期体检健康人员80例纳入对照组。两组均接受肝纤四项联合血小板检测。以肝穿刺活检结果作为金标准,分析比较两组的检测结果,对比不同肝纤维化程度患者的检测结果,分析肝纤四项及血小板计数(Platelet count,PLT)检测对肝纤维化诊断的效能。结果:较之对照组,研究组血清Ⅳ型胶原(Collage typeⅣ,colⅣ)、Ⅲ型前胶原N端肽(Ⅲprocollagen amino-terminal peptide,PⅢNP)、层粘连蛋白(Laminin,LN)、透明质酸酶(Hyaluronidase,HA)水平均明显更高,PLT水平则明显更低,P<0.05;较之轻度肝纤维化患者,中度肝纤维化患者血清colⅣ、PⅢNP、LN、HA水平均明显更高,PLT水平则明显更低,P<0.05。较之肝纤四项检查及PLT检测,肝纤四项联合PLT检测诊断肝纤维化的准确性、敏感性、特异性及与肝穿刺活检结果的一致性强度均明显更高;较之PLT检测,肝纤四项检查诊断肝纤维化的准确性、敏感性、特异性及与肝穿刺活检结果的一致性强度均明显更高,P<0.05。结论:肝纤四项联合血小板检测在肝纤维化诊断中的应用价值颇高,不仅可预测肝纤维化的严重程度,还有助于早期肝纤维化检出。

Objective:To investigate the application value of liver fibronectin combined with platelet detection in the diagnosis of liver fibrosis.Methods:80 patients with suspected liver fibrosis admitted to our hospital from November 2021 to June 2023 were selected as research objects and included in the study group.A total of 80 healthy subjects were included in the control group.Both groups underwent liver fibra-four combined platelet tests.With the results of liver biopsy as the gold standard,the detection results of the two groups were analyzed and compared,and the detection results of patients with different degrees of liver fibrosis were compared,and the efficacy of liver fibre-four and the platelet count(PLT)detection in the diagnosis of liver fibrosis was analyzed.Results:Compared with the control group,the serum levels of typeⅣcollagen(colⅣ),typeⅢprocollagen N-terminal peptide(PⅲNP),laminin(LN)and hyaluronic acid prume(HA)in the study group were significantly higher,and PLT level was significantly lower,P<0.05;Compared with patients with mild liver fibrosis,serum colⅣ,PⅲNP,LN and HA levels in patients with moderate liver fibrosis were significantly higher,while PLT levels were significantly lower(P<0.05).The accuracy,sensitivity,specificity,and consistency with the results of liver biopsy were significantly higher than that of the four tests and PLT in the diagnosis of liver fibrosis.Compared with PLT test,the accuracy,sensitivity,specificity,and consistency with the results of liver biopsy were significantly higher in the diagnosis of liver fibrosis(P<0.05).Conclusion:The application value of liver fibronectin combined with platelet test is very high in the diagnosis of liver fibrosis,which can not only predict the severity of liver fibrosis,but also contribute to the early detection of liver fibrosis.