LED窄谱长波紫外线+红外线双波长照射联合8-MOP外搽治疗白癜风的临床效果

Clinical effect of LED narrow-spectrum UVA+infrared dual wavelength irradiation combined with 8-MOP external liniment in treatment of vitiligo

目的:探究LED窄谱长波紫外线(UVA)+红外线(IR)双波长照射联合甲氧沙林溶液(8-MOP)外搽治疗白癜风的临床效果。方法:我院于2021年1月-2023年6月收治的白癜风患者68例,通过随机数表法分为对照组与实验组,每组各34例。对照组于白癜风皮损处涂抹8-MOP,后行UVB照射治疗。实验组涂抹8-MOP后,给予IR照射和UVA照射治疗。治疗结束前后记录患者皮损面积,治疗结束后评价两组疗效,并观察记录两组治疗期间皮肤灼烧感、刺痛感、红肿、水泡。结果:实验组总有效率为85.29%,显著高于对照组总有效率64.71%(P<0.05)。经过干预后两组治疗后皮损面积明显减少(P<0.05),且实验组明显小于对照组(P<0.05)。两组治疗期间皮肤灼烧感、刺痛感、红肿、水泡发生率差异无统计意义(P>0.05)。结论:LEDUVA+IR双波长照射联合8-MOP外搽治疗白癜风患者临床效果明确,安全可靠。

Objective:To investigate the clinical effect of LED narrow-spectrum long wave ultraviolet(UVA)+infrared(IR)dual wavelength irradiation combined with methoxalin solution(8-MOP)on the treatment of vitiligo.Methods:68 cases of vitiligo treated in our hospital from January 2021 to June 2023 were divided into control group and experimental group by random number table,34 cases in each group.In the control group,8-MOP was applied on the vitiligo lesions,followed by UVB irradiation.The experimental group was treated with IR irradiation and UVA irradiation after applying 8-MOP.The skin area of patients was recorded before and after treatment,and the curative effect of the two groups was evaluated after treatment,and the skin burning,tingling,redness and blisters in the two groups were observed and recorded during treatment.Results:The total effective rate of the experimental group was 85.29%,which was significantly higher than that of the control group 64.71%(P<0.05).After the intervention,the skin area of the two groups was significantly reduced after treatment(P<0.05),and the experimental group was significantly smaller than the control group(P<0.05).There was no statistical significance in the incidence of skin burning,stinging,redness and blisters between the two groups during treatment(P>0.05).Conclusion:LEDUVA+IR dual wavelength irradiation combined with 8-MOP external liniment in the treatment of vitiligo patients is safe and effective.