腹腔镜下手术治疗结直肠癌患者临床疗效及免疫功能与细胞因子的影响

Effects of laparoscopic surgery on the clinical efficacy and immune function and cytokines in patients with colorectal cancer

目的:分析腹腔镜下手术治疗结直肠癌患者临床疗效及免疫功能与细胞因子的影响。方法:回顾性选取2020年5月至2022年11月本院收治结直肠癌患者103例的临床资料,根据手术方案的不同将患者分为对照组(行传统结直肠癌根治术,n=48)和观察组(行腹腔镜下手术,n=55)。治疗1 m后分析两组的临床疗效,采用流式细胞术测定免疫功能,采用双抗体夹心酶联免疫吸附法检测生长分化因子-15(Growth differentiation factor 15,GDF-15)、重组人碱性成纤维细胞生长因子(Recombinant human basic fibroblast growth factor,b-FGF)水平。结果:观察组总疗效显著高于对照组(P<0.05)。两组术后CD8^(+)均下降,CD4^(+)、CD4^(+)/CD8^(+)均上升。观察组CD8^(+)显著低于对照组,CD4^(+)、CD4^(+)/CD8^(+)均显著高于对照组(P<0.05)。两组术后GDF-15、b-FGF水平均下降,且观察组GDF-15、b-FGF水平均显著低于对照组(P<0.05)。结论:腹腔镜下手术治疗结直肠癌,能提高临床疗效,改善免疫功能,降低细胞因子水平。

Objective:To analyze the clinical efficacy,immune function and cytokine effects of laparoscopic surgery in patients with colorectal cancer.Methods:Clinical data of 103 patients with colorectal cancer admitted to our hospital from May 2020 to November 2022 were retrospectively selected,and the patients were divided into control group(traditional radical resection of colorectal cancer,n=48)and observation group(laparoscopic surgery,n=55)according to different surgical protocols.After 1 month of treatment,the clinical efficacy of the two groups was analyzed,the immune function was measured by flow cytometry,and Growth differentiation factor 15(GDF-15),Recombinant human basic fibroblast growth factor(b-FGF)levels was detected by double antibody sandwich enzyme-linked immunosorbent assay.Results:The total curative effect of observation group was significantly higher than that of control group(P<0.05).Postoperative CD8^(+)decreased in both groups,while CD4^(+)and CD4^(+)/CD8^(+)increased.CD8^(+)in observation group was significantly lower than that in control group,and CD4^(+)and CD4^(+)/CD8^(+)were significantly higher than those in control group(P<0.05).The levels of GDF-15 and b-FGF in both groups decreased after operation,and the levels of GDF-15 and b-FGF in observation group were significantly lower than those in control group(P<0.05).Conclusion:Laparoscopic surgery for colorectal cancer can improve clinical efficacy,improve immune function and reduce cytokine levels.