摘要
An acetic acid-promoted C(sp^(3))-H functionalization of 2-methyl quinoline,enaminoesters and elemental sulfur for the synthesis of 3,4,5-trisubstituted isothiazoles under metal-free conditions has been developed.This approach provides viable access to various 5-(quinolin-2-yl)isothiazoles in moderate to good yields with good functional group tolerance.Moreover,the success of the gram-scale reaction gives this reaction a great potential application.
基金
Support by the National Natural Science Foundation of China(Nos.22271244,21871226 and 21572194)
Postgraduate Scientific Research Innovation Project of Hunan Province(No.CX20200631)
the Open Research Fund of the School of Chemistry and Chemical Engineering of Henan Normal University(No.2022C02)is gratefully acknowledged.
