某院国家基本药物不良反应报告分析

Analysis of Adverse Reactions of National Essential Drugs in A Hospital

目的 了解现有国家基本药物发生药品不良反应(ADR)的情况和特点,促进基本药物安全、合理使用。方法 采用回顾性研究方法,依据2018版《国家基本药物目录》,抽取2019年1—12月蚌埠市第三人民医院上报的110份国家基本药物ADR报告进行统计分析。结果 ADR主要发生在年龄≥60岁人群(68例,61.8%);静脉滴注给药途径发生ADR患者73例(66.4%);引起ADR前两位的药品种类分别为抗肿瘤药(44例,40.0%)、抗微生物药(29例,26.4%);ADR主要累及消化系统(34例,29.6%)和皮肤附件(20例,17.4%),临床表现为恶心、皮疹、瘙痒、呕吐等。结论 加强国家基本药物ADR的预防和监测,保障患者用药安全。

Objective To understand the situation and characteristics of adverse drug reactions(ADRs)of existing national essential drugs,and promote the safe and rational use of essential drugs.Methods According to the 2018 edition of the National Essential Drugs Catalogue,110 national essential drug ADR reports reported by Bengbu Third People's Hospital from January 2019 to December 2019 were selected by retrospective study method,and the extracted reports were statistically analyzed.Results ADR mainly occurred in people aged≥60 years(68 cases,61.8%).ADR occurred in 73 cases(66.4%)by intravenous drip.The top two drugs causing ADR were anti-tumor drugs(44 cases,40.0%)and antimicrobial drugs(29 cases,26.4%).ADR mainly involved in digestive system(34 cases,29.6%)and skin appendages(20 cases,17.4%).The clinical manifestations were nausea,rash,itching and vomiting.Conclusion Strengthen the prevention and monitoring of ADR of national essential drugs to ensure the safety of basic drugs.