女性常见生殖内分泌疾病与微生物组关系的研究进展

Progress of research on the relationship between common female reproductive endocrine diseases and microbiome

女性生殖内分泌相关疾病严重影响女性生殖健康及生活质量,其中多囊卵巢综合征和早发性卵巢功能不全是育龄期女性最常见的两种生殖内分泌疾病。而随着微生物组学技术的不断发展,人体共生微生物已被证实与多种内分泌代谢疾病相关。越来越多研究表明肠道及生殖道微生物组与女性生殖内分泌疾病密不可分,在疾病发生、发展过程中起着重要作用。本文拟就多囊卵巢综合征和早发性卵巢功能不全和肠道、生殖道微生物组之间的关系进行综述,并探讨微生态制剂的应用,以期为女性生殖内分泌的临床诊治提供新的思路。

Female reproductive endocrine diseases seriously affect female reproductive health and quality of life,among which polycystic ovary syndrome and premature ovarian insufficiency are the two most common reproductive endocrine diseases of women of childbearing age.With the continuous development of microbiology technology,human symbiotic microbiota have been proved to be related to various endocrine and metabolic diseases.More and more studies have shown that intestinal and reproductive tract microbiome are closely related to female reproductive endocrine diseases and play an important role in the occurrence and development of diseases.This article reviews the relationship between two kinds of female reproductive endocrine diseases and microbiome of intestinal tract and reproductive tract,and discusses the application of microecological preparation in order to provide new ideas for clinical diagnosis and treatment of female reproductive endocrine.