肠道微生物群与早期自然流产病因相关性的研究进展

Interactions between gut microbiota and the etiology of early spontaneous abortion

肠道微生物在维持宿主体内代谢稳态及宿主代谢性疾病发生发展过程中发挥重要作用,其通过代谢物与宿主相互作用,对机体代谢和免疫调节等生理病理过程产生影响。早期流产是常见妊娠并发症之一,占所有临床妊娠的10%~15%。既往研究表明,肠道微生物群在妊娠并发症的病理生理过程中发挥着重要的作用,有望成为早期自然流产临床预防和治疗的新候选者。早期自然流产与肠道微生物之间的相关性得到越来越多的关注,但肠道微生物群影响早期自然流产的机制需要进一步研究。本文综述了肠道微生物群与早期自然流产发病原因的相关性,显示其可能通过调节人体内分泌、免疫功能、子宫环境参与了早期自然流产的发生发展,希望能够为临床诊治及研究提供新的思路。

Gut microbiota plays an important role in maintaining metabolic homeostasis as well as the occurrence and development of metabolic diseases in the host.Physiological and pathological processes such as body metabolism and immune regulation are impacted by the interaction of metabolites of gut microbiota with the host.Early spontaneous abortion is one of the most common pregnancy complications,accounting for 10%-15%of all clinical pregnancies.According to the previous studies,gut microbiota had an important effect in the pathophysiological process of pregnancy complications and was expected to be a new candidate for clinical prevention and treatment of early spontaneous abortion.While the correlation between early spontaneous abortion and gut microbiota has gained attention,further investigation is needed to understand the mechanism by which the gut microbiota affects early abortion.In this review,we discussed the influence of gut microbiota on early spontaneous abortion.We found that gut microbiota may participate in the development of early spontaneous abortion by regulating human endocrine,immune functions and uterine environment,hoping to provide new ideas for clinical diagnosis and treatments.