胆总管结石患者血清hs-CRP,MFG-E8的表达及其与胆道炎症的相关性研究

Expression of serum hs-CRP,MFG-E8 in patients with common bile duct stones and their correlation with biliary inflamma-tion

目的 探究胆总管结石患者血清超敏C反应蛋白(hs-CRP)和乳脂球表皮生长因子8(MFG-E8)的表达及其与胆道炎症的相关性.方法 选取我院2022年1月~2023年5月期间收治的89例胆囊结石合并胆总管结石患者作为研究组,并根据胆道炎症严重程度分为轻度组(29例)、中度组(41例)和重度组(19例),另选取同期在本院体检,且一般资料与研究组患者相匹配的89例健康者作为对照组.采用Pearson法分析血清hs-CRP和MFG-E8表达水平的相关性;采用受试者工作特征(ROC)曲线分析血清hs-CRP和MFG-E8对胆总管结石的诊断价值.结果 研究组血清hs-CRP表达水平高于对照组,MFG-E8则低于对照组(P<0.05);血清hs-CRP和MFG-E8表达水平呈负相关(r=-0.653,P<0.05);血清hs-CRP表达水平随胆道炎症严重程度的增加而升高(P<0.05),血清MFG-E8表达水平的变化趋势则与之相反;血清hs-CRP和MFG-E8单独诊断胆总管结石的曲线下面积(AUC)分别为0.867、0.879,而二者联合诊断的AUC为0.960,优于各自单独诊断(Z二者联合-hs-CRP=4.039、Z二者联合-MFG-E8=3.830,P均<0.05).结论 血清hs-CRP和MFG-E8表达与胆总管结石的发生以及胆道炎症严重程度具有一定的相关性,二者联合检测对胆总管结石具有较高的诊断价值.

Objective To investigate the expression of serum high sensitivity C-reactive protein(hs-CRP)and milk fat glob-ule EGF factor 8(MFG-E8)in patients with common bile duct stones and their correlation with biliary inflammation.Methods From January 2022 to May 2023,89 patients with gallbladder stones combined with common bile duct stones admitted to our hospital were collected as the study group,and were grouped into mild group(29 cases),moderate group(41 cases),and severe group(19 cases)based on the severity of biliary inflammation.Additionally,89 healthy individuals who underwent physical examination in our hospital and matched general information with the study group were collected as the control group.Pearson method was applied to analyze the correlation between serum hs-CRP and MFG-E8 expression levels;receiver operating characteristic(ROC)curve was applied to ana-lyze the diagnostic value of serum hs-CRP and MFG-E8 for common bile duct stones.Results The expression level of serum hs-CRP in the study group was higher than that in the control group,while MFG-E8 was lower than that in the control group(P<0.05);the expression levels of serum hs-CRP and MFG-E8 were negatively correlated(r=-0.653,P<0.05);the expression level of serum hs-CRP increased with the severity of biliary inflammation(P<0.05),while the trend of changes in serum MFG-E8 expression level was opposite;the area under the curve(AUC)of serum hs-CRP and MFG-E8 for diagnosing common bile duct stones alone was 0.867 and 0.879,respectively,the AUC of the combined diagnosis of the two was 0.960,which was better than the individual diagnosis(Z com-bination-hs-CRP=4.039,Z combination-MFG-E8=3.830,P<0.05).Conclusion There is a certain correlation between the ex-pression of serum hs-CRP and MFG-E8 and the occurrence of common bile duct stones and the severity of biliary inflammation.The combined detection of the two has high diagnostic value for common bile duct stones.