单核细胞计数/高密度脂蛋白胆固醇比值与急性胰腺炎的相关性研究

The correlation between monocyte count/high-density lipoprotein cholesterol ratio and acute pancreatitis

目的研究单核细胞计数/高密度脂蛋白胆固醇比值(MHR)和急性胰腺炎(AP)的相关性.方法选取AP患者100例为AP组,收集其临床资料,并对所有患者进行MHR及急性胰腺炎严重程度床边指数(BISAP)评分计算.同时选取健康体检者30例为对照(CON)组.分析MHR与AP之间的相关性.结果AP组MHR高于CON组(P<0.05),MHR与BISAP评分正相关(p=0.460,P<0.05);MHR为AP的独立危险因素[OR=1.018,95%CI(1.009,1.026)];ROC曲线分析显示MHR预测AP的曲线下面积(area under curve,AUC)为0.913,截断值为390.3时,预估AP的敏感度和特异度分别为83%和90%.结论MHR是AP的危险因素,对AP的发生具有预测价值.

Objective To study the relationship between monocyte count high-density lipoprotein cholesterol ratio(MHR)and acute pancreatitis cholesterol(AP).Methods One hundred patients with AP were selected as AP group and their clinical data were collected.MHR and bedside index for severity in acute pancreatitis(BISAP)scores were calculated for all patients.Meanwhile,30 healthy subjects were selected as control(CON)group.The correlation between MHR and AP was analyzed.Results MHR in AP group was higher than that in CON group(P<0.05),and MHR was positively correlated with BISAP score(p=0.460,P<0.05).MHR was an independent risk factor for AP[OR=1.018,95%CI(1.009,1.026)].Receiver operating characteristic analysis showed that the area under curve(AUC)of MHR predicted AP was 0.913,and the sensitivity and specificity of predicted AP were 83%and 90%respectively when the cutoff value was 390.3.Conclusions MHR is a risk factor for AP and has a predictive value for the occurrence of AP.