经典名方温胆汤及其类方治疗眩晕的药理与临床研究进展

Pharmacological and clinical studies on treatment of vertigo by classical formula Wendan Decotion and its analogues

温胆汤是经典的祛痰名方,广泛应用于神经系统、循环系统、内分泌系统、消化系统疾病。药理研究显示,温胆汤及其类方(加味温胆汤、黄连温胆汤、柴白温胆汤)具有抗炎、调节糖脂代谢、抗抑郁、抗氧化的作用,通过减轻细胞炎症反应、抑制游离脂肪酸的表达以及促进超氧化物歧化酶(SOD)的表达而治疗眩晕。对温胆汤及其类方治疗眩晕的药理及临床研究进展进行综述,以期为治疗眩晕的新药研发及临床合理用药提供依据。

Wendan Decoction is a classic expectorant formula widely used in diseases of the nervous system,circulatory system,endocrine system and digestive system.Modern studies have shown that Wendan Decoction and its analogs(Jiawei Wendan Decoction,Huanglian Wendan Decoction,Chaibai Wendan Decoction)have anti-inflammatory,glycolipid metabolism regulating,antidepressant and antioxidant effects,and can treat vertigo by decreasing cellular inflammation,inhibiting the expression of free fatty acids,and promoting the expression of superoxide dismutase(SOD).The pharmacological effects of Wendan Decoction and its analogous formulas and their applications in vertigo are reviewed,with a view to providing a basis for the development of new drugs for the treatment of vertigo and the rational use of drugs in the clinic.