摘要
目的:考察引起盐酸溴己新注射剂临床应用吸附性丢失的因素.方法:采用析因实验设计,考察给药途径中输液容器、输液器相关因素引起的主药含量变化以确认临床应用过程中的吸附性丢失情况.结果:玻璃瓶材质的输液容器几乎无吸附影响,输液软袋、生理盐水溶媒影响较突出,聚氯乙烯输液器(PVC)影响较大.结论:建议本品输液优选玻璃瓶包装的葡萄糖注射液,以降低给药剂量的丢失.
Objective:To investigate the factors causing adsorbable loss of bromhexine hydrochloride injections in clinical application.Methods:Factorial experimental design was used to investigate the changes of active pharmaceutical ingredient content caused by the factors related to the infusion containers and infusion sets in the administration route to confirm the loss of adsorption during clinical application.Results:In regard of the adsorbable loss of active pharmaceutical ingredient,the glass infusion container had almost no effect,the infusion soft bag and normal saline solvent had significant effects,and the polyvinyl chloride infusion set had a greater effect.Conclusion:It is suggested that glucose injection packaged in glass bottle be preferred for infusion of bromhexine hydrochloride injections to reduce the adsorbable loss of active pharmaceutical ingredient.
作者
刘毅
刘晓强
李选堂
姚晓
郭贤辉
林兰
LIU Yi;LIU Xiao-qiang;LI Xuan-tang;YAO Xiao;GUO Xian-hui;LIN Lan(National Institutes for Food and Drug Control,Bejing 102629,China;Changzhou Institute for Drug Control,Changzhou 213002,China)
出处
《中国新药杂志》
CAS
CSCD
北大核心
2024年第2期194-197,共4页
Chinese Journal of New Drugs
关键词
注射用盐酸溴己新
盐酸溴己新葡萄糖注射液
盐酸溴己新注射液
吸附性
临床应用
bromhexin hydrochloride for injection
bromhexine hydrochloride and glucose injection
bromhexine hydrochloride injection
adsorbability
clinical application