氯吡格雷联合血管内介入治疗在急性缺血性脑血管病患者中的应用效果评估

Evaluation of the Application Effect of Clopidogrel Combined with Endovascular Intervention in Patients with Acute Ischemic Cerebrovascular Disease

目的 探讨氯吡格雷+血管内介入用于急性缺血性脑血管病患者中的应用效果。方法 方便选取2021年4月—2023年4月武平县医院收治的98例急性缺血性脑血管病患者为研究对象,按奇偶分组法分为两组,每组49例。参照组应用血管内介入治疗方案,研究组采取氯吡格雷联合血管内介入治疗方案。比较两组治疗前后的凝血功能、脑血流参数、临床疗效。结果 治疗后,研究组纤维蛋白原低于参照组,凝血酶时间、凝血酶原时间、活化部分凝血活酶时间等均长于参照组,差异有统计学意义(P均<0.05)。治疗后,研究组血流相关指标高于参照组,差异有统计学意义(P<0.05)。研究组治疗总有效率为95.91%,高于参照组的83.67%,差异有统计学意义(χ^(2)=4.009,P<0.05)。结论 氯吡格雷联合血管内介入治疗方案的应用,对提高急性缺血性脑血管病患者的整体治疗效果作用显著。同时,该治疗方案在改善患者脑血流参数方面优势明显,可改善其凝血功能。

Objective To investigate the application effect of clopidogrel + endovascular intervention used in patients with acute ischemic cerebrovascular disease.Methods 98 patients with acute ischemic cerebrovascular disease admitted to Wuping County Hospital from April 2021 to April 2023 were conveniently selected as the study subjects,and were divided into two groups of 49 cases each according to the odd-even grouping method.The reference group applied endovascular intervention treatment program,and the study group adopted clopidogrel combined with endovascular intervention treatment program.The coagulation function,cerebral blood flow parameters,and clinical efficacy of the two groups before and after treatment were compared.Results After treatment,fibrinogen of the study group was lower than that of the reference group,and thrombin time,prothrombin time and activated partial thromboplastin time were longer than those of the reference group,and the differences were statistically significant(all P<0.05).After treatment,the values of blood flow-related indexes in the study group were higher than those in the reference group,and the differences were statistically significant(P<0.05).The total effective rate of treatment in the study group was 95.91%,which was higher than 83.67% in the reference group,and the difference was statistically significant(χ^(2)=4.009,P<0.05).Conclusion The application of clopidogrel combined with endovascular interventional therapy program plays a significant role in improving the overall treatment effect of patients with acute ischemic cerebrovascular disease.At the same time,this treatment program has clear advantages in improving the cerebral blood flow parameters of the patients,and can improve their coagulation function.