乳腺癌患者的生活质量与更年期症状严重程度的相关性研究

Study on Correlation between Quality of Life and Severity of Menopausal Symptoms in Patients with Breast Cancer

目的:探究乳腺癌患者的生活质量与更年期症状严重程度的相关性,为临床不同乳腺癌患者的针对性心理治疗提供参考。方法:选取2021年10月—2022年12月江南大学附属医院收治的178例乳腺癌患者作为研究对象,采用Kupperman量表判断患者的更年期症状严重程度,采用医院焦虑抑郁量表(hospital anxiety and depression scale,HADS)、癌症治疗功能评估问卷(functional assessment of cancer therapy,FACT)G/B评估患者的心理状况和生活质量,分析和评估乳腺癌患者的生活质量与更年期症状严重程度的相关性。结果:根据Kupperman量表,178例乳腺癌患者中,无更年期症状的有72例(设为无症状组),有轻度更年期症状的有38例(设为轻症组),有中度更年期症状的有54例(设为中症组),有重度更年期症状的有14例(设为重症组);接受内分泌治疗与否将影响乳腺癌患者更年期症状的严重程度(P<0.01),其中接受内分泌治疗患者重度更年期症状的发生率更高(15.38%vs 3.54%,P<0.05);HADS评分结果显示,患者更年期症状越重,其焦虑和抑郁的倾向越明显(P<0.01);FACT评分结果显示,患者的更年期症状越轻,其整体生活质量和乳腺癌症状越良好(P<0.01),并且在生理状况、情感状况、功能状况等分项表现也越好(P<0.05)。结论:乳腺癌患者更年期症状的严重程度确实会影响其心理状况和生活质量,而更年期症状的轻重可能与是否接受内分泌治疗有关,为此临床应尽可能控制和改善乳腺癌患者的更年期症状,使其获得更好的生活质量。

Objective:To explore the correlation between quality of life and severity of menopausal symptoms in patients with breast cancer and provide reference for targeted psychological treatment of different patients with breast cancer.Methods:A total of 178 patients with breast cancer admitted to the Affiliated Hospital of Jiangnan University from October 2021 to December 2022 were selected as the research subjects.The Kupperman index was used to judge the severity of the patients' menopausal symptoms,and the Hospital Anxiety and Depression Scale(HADS) and Functional Assessment of Cancer Therapy(FACT) G/B were used to assess the psychological status and quality of life of patients,to analyze and evaluate the correlation between quality of life and severity of menopausal symptoms in patients with breast cancer.Results:According to the Kupperman index,among 178 patients with breast cancer,72 patients had no menopausal symptoms(asymptomatic group),38 patients had mild menopausal symptoms(mild symptom group),54patients had moderate menopausal symptoms(moderate symptom group) and 14 patients had severe menopausal symptoms(severe symptom group).Whether the endocrine therapy was received will affect the severity of menopausal symptoms in patients with breast cancer(P<0.01),among which,the incidence of severe menopausal symptoms in patients receiving endocrine therapy was higher(15.38% vs 3.54%,P<0.05);HADS scoring results showed that the severer the menopausal symptoms were,the more obvious the tendency of anxiety and depression(P<0.01);the FACT scoring results showed that the milder the patients' menopausal symptoms were,the better their overall quality of life and breast cancer symptoms(P<0.01),and the better the patients' physical well-being,emotional well-being and functional well-being,etc.(P<0.05).Conclusion:The severity of menopausal symptoms in patients with breast cancer indeed affects their psychological status and quality of life,and the severity of menopausal symptoms may be related to whether they receive endocrine therapy.Therefore,clinically,the menopausal symptoms of patients with breast cancer shall be controlled and improved as much as possible,so that they can obtain better quality of life.