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利拉鲁肽联合二甲双胍治疗2型糖尿病合并非酒精性脂肪肝的疗效研究 被引量:1

Efficacy of Liraglutide Combined with Metformin in the Treatment of Type 2 Diabetes Mellitus with Nonalcoholic Fatty Liver Disease
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摘要 目的分析利拉鲁肽联合二甲双胍治疗2型糖尿病(type 2 diabetes mellitus,T2DM)合并非酒精性脂肪肝(nonalcoholic fatty liver disease,NAFLD)患者的疗效。方法选取2019年6月—2021年5月江苏省泗洪中信医院收治的86例2型糖尿病合并非酒精性脂肪肝患者作为研究对象,采用随机数表法分为对照组与观察组各43例。对照组采用二甲双胍联合胰岛素治疗,观察组采用二甲双胍联合利拉鲁肽治疗。比较两组患者血糖控制水平、肝功能水平、血脂水平。结果与对照组相比,观察组患者血糖控制水平好转、肝功能好转、血脂指标降低,差异有统计学意义(P均<0.05)。结论2型糖尿病合并非酒精性脂肪肝患者采用利拉鲁肽联合二甲双胍治疗时控制血糖效果好,同时改善患者的肝脏功能,是安全且可靠的治疗方案。 Objective To analyze the efficacy of liraglutide combined with metformin in the treatment of type 2 diabe-tes mellitus(T2DM)with nonalcoholic fatty liver disease(NAFLD).Methods A total of 86 patients with T2DM compli-cated with NAFLD admitted to Sihong Zhongxin Hospital of Jiangsu Province from June 2019 to May 2021 were se-lected and divided into control group and observation group with 43 cases in each group by random number table method.Control group was treated with metformin combined with insulin,observation group was treated with metfor-min combined with liraglutide.The blood glucose control level,liver function level and blood lipid level were com-pared between the two groups.Results Compared with the control group,the blood glucose control level was im-proved,the liver function was improved,and the blood lipid index was decreased in the observation group,the differ-ences were statistically significant(all P<0.05).Conclusion In T2DM patients with NAFLD,liraglutide combined with metformin can control blood glucose effectively and improve liver function at the same time,which is a safe and reliable treatment plan.
作者 宋光永 蒋琳 SONG Guangyong;JIANG Lin(Department of Endocrinology,Zhongxin Hospital,Sihong,Jiangsu Province,223900 China;Department of Endocrinology,Jiangsu Provincial People's Hospital,Sihong,Jiangsu Province,210000 China)
出处 《糖尿病新世界》 2023年第24期96-99,共4页 Diabetes New World Magazine
关键词 利拉鲁肽 二甲双胍 非酒精性脂肪肝 2型糖尿病 Liraglutide Metformin Nonalcoholic fatty liver Type 2 diabetes mellitus
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