血清Gal-3、PLGF与重度子痫前期患者胎盘早剥的关系

Relationship Between Serum Gal-3,PLGF and Placental Abruption in Patients with Severe Preeclampsia

目的 观察重度子痫前期患者血清半乳糖凝集素3(Gal-3)、胎盘生长因子(PLGF)表达情况及其与胎盘早剥的关系。方法 选取2019年1月至2021年1月南阳市第一人民医院接受诊疗的98例重度子痫前期患者为研究对象,统计患者胎盘早剥情况并将其分为胎盘早剥组与无胎盘早剥组,所有患者入院时均接受血清Gal-3、PLGF检测,分析重度子痫前期患者血清Gal-3、PLGF与胎盘早剥的关系。结果 98例重度子痫前期患者中发生胎盘早剥17例,占17.35%;胎盘早剥组血清Gal-3水平高于无胎盘早剥组,血清PLGF、血红蛋白水平低于无胎盘早剥组,差异有统计学意义(P<0.05);经logistic回归分析,结果显示,Gal-3、PLGF、血红蛋白异常表达与中度子痫前期患者胎盘早剥有关(P<0.05);绘制受试者工作特征曲线,结果显示,血清Gal-3、PLGF预测重度子痫前期患者胎盘早剥发生的AUC均>0.8,具有一定预测价值,且联合检测的价值最高。结论 重度子痫前期胎盘早剥患者Gal-3呈高表达,PLGF呈低表达,且血清Gal-3、PLGF水平与重度子痫前期患者胎盘早剥密切相关。

Objective To observe the expression of serum galectin-3(Gal-3)and placental growth factor(PLGF)in patients with severe preeclampsia and their relationship with placental abruption.Methods A total of 98 patients with severe preeclampsia treated in Nanyang First People’s Hospital from January 2019 to January 2021 were selected as the research subjects,the placental abruption of patients was counted and divided them into placental abruption group and non placental abruption group.All patients received serum Gal-3 and PLGF levels at admission,and the relationship between serum Gal-3,PLGF and placental abruption in patients with severe preeclampsia were analyzed.Results Among 98 patients with severe preeclampsia,placental abruption occurred in 17 cases,accounting for 17.35%.The levels of serum Gal-3 in placental abruption group were higher than those in non placental abruption group,and the levels of serum PLGF and hemoglobin were lower than those in non placental abruption group,the differences were statistically significant(P<0.05).Through logistic regression analysis,the results showed that,the abnormal expressions of Gal-3,PLGF and hemoglobin were related to placental abruption in patients with moderate preeclampsia(P<0.05).The receiver operating characteristic curve was drawn,and the results showed that,the AUC of serum Gal-3 and PLGF in predicting placental abruption in patients with severe preeclampsia were>0.8,which had certain predictive value,and the value of joint detection was the highest.Conclusion The expression of Gal-3 is high and PLGF is low in patients with severe preeclampsia and placental abruption,and the levels of serum Gal-3 and PLGF are closely related to placental abruption in patients with severe preeclampsia.