一例免疫抑制状态骨髓炎患者的抗感染治疗用药分析和药学监护

Analysis of drug use of anti-infective therapy and pharmaceutical care in a case of osteomyelitis with immunosuppression

目的免疫抑制状态的骨髓炎患者的抗菌药物给药方法及临床药师在参与药物治疗中的作用。方法临床药师参与1例免疫抑制状态混合细菌感染患者抗感染治疗的全过程,基于病原菌的药敏结果、抗菌药物特性等分析抗菌药物的品种选择及替加环素初始给药剂量、给药方式的调整。结果患者感染得到控制,未发生明显的不良反应。结论在免疫抑制骨髓炎患者的治疗中,临床药师发挥专业优势,可协助医师优化抗感染治疗方案,提高临床疗效。

Objective To investigate the methods of antimicrobial administration in patients with osteomyelitis in immunosuppression and the role of clinical pharmacists in drug therapy.Methods A clinical pharmacist participated in the whole course of anti-infection treatment for a patient with mixed bacterial infection in immunosuppression,the selection of antimicrobial agents and the adjustment of initial dosage and mode of administration of tegecycline were analyzed based on the results of antimicrobial susceptibility test and antimicrobial characteristics.Results The infection was controlled and no obvious adverse reaction occurred.Conclusion In the treatment of patients with immunosuppressive osteomyelitis,clinical pharmacists play a professional advantage,can help doctors optimize anti-infection treatment,improve clinical efficacy.