血脂和身体质量指数与幽门螺杆菌感染的关系研究

Correlation of blood lipids and body mass index with Helicobacter pylori infection

目的探讨血脂和身体质量指数(BMI)与幽门螺杆菌(Hp)感染的关系。方法采用病例对照研究,选取解放军联勤保障部队第九〇三医院2022年5月至2023年5月健康体检者303例为研究对象,根据是否发生Hp感染分为Hp感染组(n=97)与无Hp感染组(n=206)。测定研究对象身高和身体质量,计算BMI;全自动生化分析仪测定血脂四项指标水平。比较Hp感染组与无Hp感染组不同BMI分布情况;比较Hp感染组与无Hp感染组血脂4项指标异常情况;采用Spearson相关性分析Hp感染与BMI和血脂四项指标的相关性;采用多因素logistic模型分析Hp感染的影响因素。结果Hp感染组24 kg/m^(2)≤BMI<28 kg/m^(2)[39.17%(38/97)]和BMI≥28 kg/m^(2)[10.31%(10/97)]均高于无Hp感染组[19.90%(41/206)和2.43%(5/206)](χ^(2)=12.71、7.11,P<0.001、0.008)。Hp感染组高密度脂蛋白胆固醇(HDL-C)下降率[23.71%(23/97)]、低密度脂蛋白胆固醇(LDL-C)升高率[31.96%(31/97)]、三酰甘油(TG)升高率[17.53%(17/97)]和总胆固醇(TC)升高率[22.68%(22/97)]均高于无Hp感染组的9.22%(19/206)、11.17%(23/206)、7.28%(15/206)和8.74%(18/206)(χ^(2)=11.59、19.47、7.33、11.19,P=0.001、<0.001、0.007、0.001)。经Spearson分析显示,Hp感染与BMI、LDL-C、TG和TC呈线性正相关(r=0.571、0.519、0.473、0.535,P<0.001),而与HDL-C呈线性负相关(r=-0.628,P<0.001)。经多因素logistic回归模型显示,BMI≥24 kg/m^(2)、HDL-C下降、LDL-C升高、TG升高和TC升高为影响Hp感染的独立危险因素。结论血脂和BMI与Hp感染密切相关,且血脂异常及BMI升高为影响Hp感染独立危险因素。

Objective To correlate blood lipids and body mass index(BMI)with Helicobacter pylori(Hp)infection.Methods A total of 303 participants who underwent physical examinations at The 903 Hospital of PLA Joint Logistics Support Force from May 2022 to May 2023 were included in this case-control study.These patients were divided into an Hp-infected group(n=97)and a non-Hp-infected group(n=206)based on whether they had Hp infection or not.Participants'body height and weight were recorded,and BMI was calculated.The levels of four blood lipid indicators were determined using an automatic biochemical analyzer.The distribution of different BMIs and abnormal statuses of these four blood lipid indicators were compared between the two groups.Spearman correlation analysis was used to analyze the correlation between Hp infection and these four blood lipid indicators.A multivariate logistic regression model was applied to analyze the influential factors for Hp infection.Results The number of participants who had 24 kg/m^(2)≤BMI<28 kg/m^(2)[39.17%(38/97)]and the number of participants who had BMI≥28 kg/m^(2)[10.31%(10/97)]in the Hp-infected group was significantly higher than those in the non-Hp-infected group[19.90%(41/206)and 2.43%(5/206),χ^(2)=12.71,7.11,P<0.001,0.008].The decrease rate of high-density lipoprotein cholesterol(HDL-C),increase rate of low-density lipoprotein cholesterol(LDL-C),increase rate of triglyceride(TG),and increase rate of total cholesterol(TC)in the Hp-infected group were 23.71%(23/97),31.96%(31/97),17.53%(17/97),and 22.68%(22/97),respectively,which were significantly higher than 9.22%(19/206),11.17%(23/206),7.28%(15/206),and 8.74%(18/206)in the non-Hp-infected group(χ^(2)=11.59,19.47,7.33,11.19,P=0.001,<0.001,0.007,0.001).The Spearman analysis showed that Hp infection was linearly positively correlated with BMI,LDL-C,TG,and TC(r=0.571,0.519,0.473,0.535,all P<0.001),while it was linearly negatively correlated with HDL-C(r=-0.628,P<0.001).Multivariate logistic regression analysis showed that BMI≥24 kg/m^(2),decreased HDL-C,increased LDL-C,elevated TG,and elevated TC are independent risk factors for Hp infection.Conclusion Blood lipids and BMI are closely associated with Hp infection,and abnormal blood lipids and elevated BMI are independent risk factors for Hp infection.