IGF-1、IGFBP-3在非小细胞肺癌组织中的表达及其临床意义

Expression and Clinical Significance of IGF-1 and IGFBP-3 in Non-small Cell LungTissue

目的 探讨类胰岛素一号生长因子(IGF-1)、胰岛素样生长因子结合蛋白-3(IGFBP-3)在非小细胞肺癌(NSCLC)患者血清和肺癌组织中的表达及临床意义。方法 收集98例NSCLC纳入观察组,同时收集肺部良性病变40例纳入对照组。统计两组血清及肺癌组织中IGF-1、IGFBP-3表达。结果 观察组血清IGF-1水平高于对照组,IGFBP-3水平低于对照组,P<0.05。血清IGF-1、IGFBP-3水平与TNM分期、淋巴结转移、局部侵犯有关,P<0.05。观察组IGF-1阳性表达率显著高于对照组,IGFBP-3阳性表达率显著低于对照组,P<0.05。IGF-1、IGFBP-3阳性表达率与TNM分期、淋巴结转移、局部侵犯有关,P<0.05。血清IGF-1诊断NSCLC AUC为0.733,灵敏度55.5%,特异度91.2%,最佳截断值150.26μg/L;血清IGFBP-3诊断NSCLC AUC为0.799,灵敏度63.6%,特异度78.6%,最佳截断值1413.54μg/L。结论 NSCLC患者血清IGF-1、IGFBP-3主要与TNM分期、淋巴结转移及局部侵犯存在关系,且血清IGF-1、IGFBP-3水平可作为NSCLC辅助诊断手段。

Objective To investigate the expression and clinical significance of IGF-1 and IGFBP-3 in serum and lung cancer tissues of patients with non small-cell lung cancer(NSCLC).Methods 98 cases of NSCLC were included in the observation group,and 40 cases of benign lung lesions were included in the control group.The expression of IGF-1 and IGFBP-3 in serum and lung cancer tissues of the 2 groups were analyzed.Results The serum IGF-1 level in the observation group was higher than that in the control group,and the serum IGFBP-3 level was lower than that in the control group,P<0.05.Serum IGF-1 and IGFBP-3 levels were correlated with TNM stage,lymph node metastasis and local invasion(P<0.05).The positive expression rate of IGF-1 and IGFBP-3 in the observation group was significantly higher than that in the control group,and the positive expression rate of IGFBP-3 was significantly lower than that in the control group,P<0.05.The positive expression rates of IGF-1 and IGFBP-3 were correlated with TNM stage,lymph node metastasis and local invasion(P<0.05).The AUC of serum IGF-1 for the diagnosis of NSCLC was 0.733,the sensitivity was 55.5%,the specificity was 91.2%,and the best cutoff value was 150.26μg/L.The AUC of serum IGFBP-3 in the diagnosis of NSCLC was 0.799,the sensitivity was 63.6%,the specificity was 78.6%,and the best cutoff value was 1413.54μg/L.Conclusion Serum IGF-1 and IGFBP-3 in patients with NSCLC are mainly related to TNM stage,lymph node metastasis and local invasion,and serum IGF-1 and IGFBP-3 levels can be used as auxiliary diagnostic means for NSCLC.