脑卒中多组学研究及其潜在意义

Multiomics research on stroke and its potential significance

脑卒中是一种急性脑血管疾病,是由于脑部血管突然破裂或因血管阻塞导致血液不能流入大脑而引起脑组织损伤的一组疾病,包括缺血性和出血性卒中。近年来,虽然脑卒中标志物研究较多,但可用于有效预警和监测的标志物却较少。组学研究是发现疾病发生发展过程中差异基因、分子及表观遗传标记的重要研究策略,本文综述了近年来脑卒中基因组学、转录组学、蛋白组学及代谢组学等重要研究成果,以及在脑卒中预警、诊断及监测中的应用潜能,以期为脑卒中标志物后续研究提供借鉴。

Stroke is an acute cerebrovascular disease,and a group of diseases that cause brain tissue damage due to sudden rupture of brain blood vessels or blockage of blood vessels,mainly including ischemic stroke and hemorrhagic stroke.In recent years,although some progresses have been achieved,there are still few biomarkers that can be used for effective warning and monitoring for people at high risk of stroke.Omics research is an important research strategy for discovering differential genes,molecules,and epigenetic markers in the process of disease occurrence and development.A systematic summary of progress made in recent years,in stroke genomics,transcriptomics,proteomics,and metabolomics in recent years,as well as their potential applications in stroke warning,diagnosis,and monitoring,was systematically discussed in the presence review,in order to provide reference for future research on stroke biomarkers.