乙酰甲胆碱(氯醋甲胆碱)支气管激发试验技术规范(2023年版)

Standard technical specifications for methacholine chloride(Methacholine)bronchial challenge test(2023)

乙酰甲胆碱支气管激发试验(MCT)是评估气道高反应性及其程度的常用检查,对支气管哮喘诊断及治疗效果评估具有重要临床价值。中国医师协会呼吸医师分会肺功能与临床呼吸生理工作委员会、中华医学会呼吸病学分会肺功能学组(筹)和中国老年医学会呼吸分会肺功能学组的专家们共同组成共识工作组,基于2014年发布的《肺功能指南——支气管激发试验检查》及其在使用中存在的问题与近年研究进展,在充分收集专家组意见、查阅文献、问卷调研、多轮线上和线下讨论后,形成了《乙酰甲胆碱(氯醋甲胆碱)支气管激发试验技术规范(2023年版)》。本共识收集了国内MCT临床实践中核心的11个问题并形成推荐意见,内容包括MCT的适应证与禁忌证、激发试剂配制、试验流程与方法、质量控制、安全性管理、结果解读和报告规范等方面,为医疗机构临床肺功能从业人员开展MCT提供参考,以期更好应用该项技术指导临床诊疗。

The methacholine challenge test(MCT)is a standard evaluation method of assessing airway hyperresponsiveness(AHR)and its severity,and has significant clinical value in the diagnosis and treatment of bronchial asthma.A consensus working group consisting of experts from the Pulmonary Function and Clinical Respiratory Physiology Committee of the Chinese Association of Chest Physicians,the Task Force for Pulmonary Function of the Chinese Thoracic Society,and the Pulmonary Function Group of Respiratory Branch of the Chinese Geriatric Society jointly developed this consensus.Based on the“Guidelines for Pulmonary Function-Bronchial Provocation Test”published in 2014,the issues encountered in its use,and recent developments,the group has updated the Standard technical specifications of methacholine chloride(methacholine)bronchial challenge test(2023).Through an extensive collection of expert opinions,literature reviews,questionnaire surveys,and multiple rounds of online and offline discussions,the consensus addressed the eleven core issues in MCT′s clinical practice,including indications,contraindications,preparation of provocative agents,test procedures and methods,quality control,safety management,interpretation of results,and reporting standards.The aim was to provide clinical pulmonary function practitioners in healthcare institutions with the tools to optimize the use of this technique to guide clinical diagnosis and treatment.