CT韧带骨赘评分在SAPHO综合征中的应用

Application of CT Osteophyte Score in SAPHO Syndrome

目的探讨和研究CT在SAPHO综合征脊柱骨赘评分中的诊断价值,并进一步研究脊柱骨赘评分与临床数据资料的相关性。方法搜集确诊的31例SAPHO综合征患者资料,所有患者均行全脊柱CT检查。依据2017年强直性脊柱炎CT韧带骨赘评分(CTSS)进行骨赘评分,计算和分析颈椎骨赘评分、胸椎骨赘评分、腰椎骨赘评分、全脊柱骨赘评分、矢状位全脊柱骨赘评分及冠状位全脊柱骨赘评分。统计和测量各项临床数据,包括年龄、病程、颈部旋转、脊柱活动度、脊柱侧弯程度、指地距、枕墙距、踝间距、ESR及CRP,分析脊柱骨赘评分与各项临床数据的相关性。结果(1)颈椎骨赘评分、胸椎骨赘评分、腰椎骨赘评分、全脊柱骨赘评分、矢状位全脊柱骨赘评分、冠状位全脊柱骨赘评分分别为19.77±19.02、42.23±29.42、25.35±19.84、87.35±56.09、60.45±20.45、37.71±29.25;(2)全脊柱骨赘评分、矢状位全脊柱骨赘评分与年龄Pearson相关性分析差异均有统计学意义,P值均<0.05,r值分别为0.599、0.610;(3)全脊柱骨赘评分与脊柱侧弯程度Pearson相关性分析差异有统计学意义,P值<0.05,r值为-0.481。结论CT可以评估SAPHO综合征患者脊柱骨赘状态,并可以进行定量分析;高龄是SAPHO综合征骨赘状态进展的危险因素,脊柱骨赘状态进展可能是脊柱侧弯程度减小的危险因素。

Objective To explore the diagnostic value of CT in spinal osteophyte score of SAPHO syndrome,and to fur-ther study the correlation between spinal osteophyte score and clinical data.Methods Data of 31 patients with SAPHO syndrome diagnosed in our hospital were collected.All patients underwent total spine CT examination.Osteophytes were scored according to the 2017 CT ligament osteophyte score(CTSS)for ankylosing spondylitis.Cervical osteophyte score,thoracic osteophyte score,lumbar osteophyte score,total spinal osteophyte score,sagittal osteophyte score and coronal osteo-phyte score were calculated and analyzed.Clinical data including age,course of disease,neck rotation,spinal range of mo-tion,degree of scoliosis,finger and ground distance,occipital wall distance,ankle distance,ESR and CRP were measured and the correlation between vertebral osteophyte score and clinical data was analyzed.Results(1)Cervical osteophyte score,thoracic osteophyte score,lumbar osteophyte score,total spinal osteophyte score,sagittal osteophyte score and coronal osteophyte score were 19.77±19.02,42.23±29.42,25.35±19.84,87.35±56.09,60.45±20.45,37.71±29.25,re-spectively;(2)Pearson correlation analysis of total vertebral osteophyte score and sagittal osteophyte score with age showed statistical significance,with P values less than 0.05 and r values of 0.599 and 0.610,respectively;(3)Pearson correlation analysis showed statistical significance between total vertebral osteophyte score and scoliosis degree,with P<0.05 and r values of-0.481,respectively.Conclusion CT can evaluate the osteophyte status of SAPHO syndrome patients,and can be used for quantitative analysis.Advanced age is a risk factor for osteophyte status progression in SAPHO syndrome,and progression of osteophyte status may be a risk factor for reduced degree of scoliosis.