代谢组学在恶性肿瘤研究中的应用进展

Advances on Application of Metabolomics in Cancer Research

代谢组学是一种系统性研究生物体内代谢物质组成和变化规律的高通量技术,以探究代谢物在生物体内的作用和调控机制。代谢重编程是恶性肿瘤的重要特征之一。在肿瘤的发生和进展过程中,生物体内代谢谱会发生变化。近年来,代谢组学技术已在恶性肿瘤研究中得到广泛应用,包括肿瘤筛查、早期诊断、疗效预测、预后评估和新药靶点研发等。全文总结代谢组学在恶性肿瘤研究进展,揭示代谢组学技术在临床应用中的潜在价值。

Metabolomics is a systematic study of the composition and changes of metabolites in the organism using high-throughput technique to explore their roles and regulatory mechanism.Metabolic reprogramming is one of the major hallmarks of malignant tumors.During the tumorigensis and progression,metabolic profiles in the organism undergo significant alterations,therefore metabolomics is an important tool in cancer research.In recent years,metabolomics techniques have been widely applied in cancer research,including cancer screening,early diagnosis,efficacy prediction,prognosis evaluation,and new drug targets identification.This paper reviews the recent advances of metabolomics in cancer research focusing on the potential value of metabolomics techniques in clinical application.