代谢重编程在肺癌中的研究进展

Advances of metabolic reprogramming in lung cancer

代谢重编程是肿瘤细胞的一个重要特征。肿瘤细胞通过重新编程代谢途径来满足快速增殖所需要的能量、物质和氧化还原力,葡萄糖代谢、谷氨酰胺代谢、脂质代谢、单碳代谢是肿瘤的重要代谢途径,靶向代谢途径可以有效抑制肿瘤生长。本文总结了肺癌中葡萄糖、脂肪、氨基酸、核苷酸等代谢的异常变化,以及相关临床药物的最新研究,旨在为肺癌的预防、早期诊断以及临床治疗用药提供新思路。

Metabolic reprogramming is an important feature of tumor cells.Tumor cells reprogram metabolic pathways to meet the energy,materials and redox power required for rapid proliferation.The metabolisms of glucose,glutamine,lipid and one⁃carbon are important metabolic pathways of tumor.Targeting metabolism pathways can effectively inhibit tumor growth.This review summarizes the abnormal metabolic changes of glucose,lipid,amino acid and nucleotide in lung cancer,as well as the latest exploration of related clinical drugs,aiming to provide new ideas for the prevention,early diagnosis and clinical treatment of lung cancer.