间质性肺疾病合并肺癌的机制及治疗进展

Mechanisms and therapeutic advancements in interstitial lung disease with lung cancer

间质性肺疾病(interstitial lung disease,ILD)患者肺癌发生率高,合并ILD的肺癌患者生存期短、病死率高、治疗难度大。ILD及肺癌有共同的危险因素及相似的发病机制。肺癌治疗常可引起ILD及ILD急性加重。一些靶向两者相似发病机制的药物在肺癌合并ILD的治疗中展现出良好疗效。本文就ILD合并肺癌的发病机制、治疗风险及治疗进展进行综述,以期提高临床医师对该病的诊治水平。

Interstitial lung disease(ILD)patients have a higher incidence of lung cancer.Patients with lung cancer combined with ILD have a shorter survival period,higher mortality rate and great treatment difficulty.ILD and lung cancer share common risk factors and similar pathogenesis.Treatment of lung cancer often causes ILD and acute exacerbation of ILD.Various agents targeting common pathogenic mechanisms of lung cancer and ILD have been demonstrated to be promising therapeutic drug in the treatmeat of lung cance combined with ILD.This article provides a comprehensive review of the pathogenesis,treatment risks,and treatment advances in ILD conlined with lung cancer,aiming to improve the diagnosis and treatment of this disease for clinical physicians.