自噬与哮喘中气道平滑肌细胞表型转化关系的研究进展

Research progress on the relationship between autophagy and phenotypic transformation of airway smooth muscle cells in asthma

支气管哮喘是常见的呼吸道疾病,发病机制尚未完全阐明。气道重塑作为哮喘的关键特征之一,在哮喘早期即可发生。气道平滑肌细胞(airway smooth muscle cell,ASMC)是哮喘气道重塑的关键靶细胞,其表型从正常收缩型向增殖/合成型转化是气道重塑的重要特征之一。ASMC具有可塑性,其表型可受多种因素调节。自噬作为真核细胞生物的一种防御性保守生物过程,近年来被证实可通过调节ASMC的表型参与气道重塑。本文针对哮喘中自噬对ASMC表型的调控机制进行综述,以期对未来研究有所启发。

Asthma,a prevalent respiratory disease,remains incompletely understood in terms of its pathogenesis.Airway remodeling,a prominent feature of asthma,occurs early in the disease process.Airway smooth muscle cells(ASMC)are recognized as a critical target in asthmatic airway remodeling,and the phenotypic transformation from normal contraction to proliferation/synthesis is one of the important characteristics of airway remodeling.Autophagy,a cellular process that serves as a defense mechanism,plays a significant regulatory role in the pathogenesis of asthma,particularly in the phenotype transformation of ASMC to promote airway remodeling.In this paper,we review the relationship between autophagy and phenotype transformation of ASMC,as well as relevant findings in the context of asthma pathogenesis,with the aim of inspiring future research endeavors in this field.