基于数据挖掘的中药治疗气阴两虚型心悸的规律分析

An analysis of the regularity of TCM medicine treatment of palpitation with deficiency of both Qi and Yin based on data mining

目的:基于数据挖掘探索气阴两虚型心悸处方中的用药规律,从中得到高频处方以及高频中药,为气阴两虚型心悸的临床治疗提供参考。方法:搜集来源于中国生物医学文献服务系统、中国知网、万方知识数据服务平台以及维普中文科技期刊数据库四个数据库中自建库到2022年10月载录的中医治疗气阴两虚型心悸的医案,筛选并录入气阴两虚型心悸医案中包含的处方,应用WPS Excel、SPSS Modeler 18.0和SPSS Statistics 20.0软件分别进行中药频数分析、关联规则分析、核心药物网络分析、系统聚类分析及因子分析。结果:纳入处方268首,共涉及中药227味,高频药物51味,温性和寒性中药分别为74味和73味,甘味中药105味,归肝经、心经中药分别为60味和55味,使用频率最高的三个处方为炙甘草汤、生脉散、桂枝甘草龙骨牡蛎汤,关联规则中支持度最高的药组为“大枣-生姜and阿胶”,可聚类为5类,因子分析共提取到公因子11个。结论:气阴两虚型心悸的治疗中,使用频率最高的三个处方为桂枝甘草龙骨牡蛎汤、炙甘草汤、生脉散,可采用调气和血、益气温阳、宁心安神的方法治疗心悸,为临床提供参考。

Objective:Based on data mining,explore the medication rules in the prescription of palpitation with deficiency of both Qi(气)and Yin(阴),obtaining high-frequency prescriptions and high-frequency TCM medicine from it,and provide reference for the clinical treatment of palpitation with deficiency of both Qi and Yin.Methods:Collect medical records of TCM treating palpitations with deficiency of both Qi and Yin from four databases:CBM,CNKI,WanFang Data,and VIP,which were self builtO and recorded until October 2022,screening and entering the prescriptions included in the medical record of palpitations with deficiency of both Qi and Yin,the software WPS Excel,SPSS Modeler 18.0 and SPSS Statistics 20.0 were used for frequency analysis,association rule analysis,core medicine network analysis,system cluster analysis and factor analysis of TCM medicine.Results:A total of 268 prescriptions were included,involving 227 TCM medicines and 51 high-frequency medicines,with 74 and 73 warm and cold medicines respectively,sweet medicine 105 flavors,with 60 and 55 medicines for liver and heart meridians respectively,three prescriptions with the highest frequency of use are the Zhigancao decoction(炙甘草汤),Shengmai San(生脉散)and the Guizhi Gancao Longgu Muli decoction(桂枝甘草龙骨牡蛎汤),the medicine group with the highest support in association rules are Dazao(Fructus Jujubae),Shengjiang(Rhizoma Zingiberis Recens)and Ejiao(Colla Corii Aaini),it can be clustered into 5 categories,and 11 common factors can be extracted from factor analysis.Conclusions:Treatment of palpitation with deficiency of both Qi and Yin,three prescriptions with the highest frequency of use are the Guizhi Gancao Longgu Muli decoction,the Zhigancao decoction and Shengmai San,the method of regulating Qi and blood,supplementing Qi and warming Yang(阳),calming the heart and calming the nerves can be used to treat palpitation,providing reference for clinical practice.