《重订古今名医临证金鉴·腹泻便秘卷》论治泄泻用药规律分析

Research on Medication Rules in the Treatment of Diarrhoea in Revisiting the Jinjian of Ancient and Modern Famous Doctors,Diarrhoea and Constipation Volume

目的:通过探讨古今名医治疗泄泻的用药规律,为临床用药提供借鉴。方法:收集整理《重订古今名医临证金鉴·腹泻便秘卷》中古今名医治疗泄泻的有效处方,共纳入49位医家治疗泄泻的处方204首,将处方所涉及的单味中药录入Excel 2022软件建立用药数据库,应用SPSS Modeler 18.0统计学软件提供的Apriori算法进行单味药物频次分析、关联分析,应用SPSS Statistics 27.0统计学软件进行聚类分析,通过多角度挖掘治疗泄泻的用药规律与特征。结果:共纳入49位名医治疗泄泻的处方204首,涉及药物230味,用药频次1731次,用药频次高达30次以上的中药有甘草、白术、茯苓、白芍、陈皮、木香等12味。关联规则按支持度≥10%、置信度≥80%,获得“茯苓+甘草→白术”“陈皮+茯苓→白术”“白芍+茯苓→白术”等11个核心药对;聚类分析得到5个组合。结论:通过药物频次分析、关联分析等方法研究古今名医治疗泄泻的用药规律与特征,为临床治疗泄泻用药提供了参考与借鉴。

Objective:To provide reference for clinical drug use by discussing the drug use rules of ancient and modern famous doctors in treating diarrhea.Methods:Collect the effective prescriptions of ancient and modern famous doctors for diarrhea in Revisiting the Jinjian of Ancient and Modern Famous Doctors,Diarrhoea and Constipation Volume,and include 204 prescriptions of 49 doctors for diarrhea.Enter the single Chinese medicine involved in the prescription into Excel 2022 to establish a drug use database.Use Apriori algorithm provided in SPSS Modeler 18.0 statistical software to analyze the frequency and correlation of single medicine,SPSS Statistics 27.0 statistical software was used to conduct cluster analysis and other multi angle mining for the rule and characteristics of drug use in the treatment of diarrhea.Results:204 prescriptions for diarrhea were included from 49 famous doctors,involving 230 drugs with 1731 times of medication frequency.12 traditional Chinese medicines with more than 30 times of medication frequency included licorice,atractylodes macrocephala,poria cocos,paeony,dried tangerine peel,and woody incense.According to the association rule,support degree≥10%,confidence degree≥80%,11 core drug pairs including“Poria cocos,Licorice,Atractylodes Macrocephala”,“Tangerine peel,Poria cocos,Atractylodes macrocephala”,“Paeony,Poria cocos,Atractylodes macrocephala”were obtained.Five combinations were obtained by cluster analysis.Conclusion:This study studied the medication regularity and characteristics of the famous doctors in ancient and modern times in treating diarrhea through drug frequency analysis,correlation analysis and other methods,so as to provide reference and reference for clinical treatment of diarrhea medication.