神经稳态理论在脑胶质瘤治疗中的实践

Practice of neural homeostasis theory in the treatment of glioma

脑胶质瘤是成人最常见的颅内原发恶性肿瘤,常侵犯重要脑功能区,对传统治疗不敏感,现有手段治疗后致死致残率高,亟需新疗法新理念的探索和应用。神经稳态对于机体正常生理功能的维持至关重要,神经稳态的失衡将导致脑胶质瘤的发生和进展。在脑胶质瘤的临床诊疗过程中,除对肿瘤进行处理外,还应识别神经稳态的失衡,并在术前、术中和术后的治疗中进行充分干预,以达到最佳的治疗效果。神经稳态理论在脑胶质瘤治疗中的探索、发展和应用,将有望改变现有诊疗模式,为脑胶质瘤的临床治疗提供全新的思路。

Glioma is the most common primary malignant brain tumor in adults.It is resistant to traditional treatments or tends to invade brain functional areas.The current treatment options often lead to high rates of disability or mortality,emphasizing the urgent need for new therapies and approaches.Neurohomeostasis,which is responsible for maintaining normal physiological functions in body,plays a critical role in the development and progression of glioma.In the clinical management of glioma,it is important not only to target the tumor cells but also to address the neurohomeostatic imbalances before,during,and after surgery,for achieving better treatment outcomes.The exploration,development,and application of the neurohomeostasis theory in glioma treatment have the potential to develop current diagnostic and therapeutic strategies,offering new perspectives for the clinical management of this condition.