新型冠状病毒感染抗生素治疗后艰难梭菌感染一例

A case of Clostridium difficile infection after antibiotic treatment for COVID-19

艰难梭菌是一种能形成孢子的厌氧革兰阳性杆菌。近10年来,艰难梭菌感染率和严重程度在全球范围内不断增加,并已成为最常见的医院获得性感染之一。其临床表现多种多样,从无症状携带者状态到不同程度的腹泻,再到最严重的危及生命的结肠炎。现报告1例新型冠状病毒感染抗生素治疗后的老年患者,短期内出现艰难梭菌感染的诊治。结合对新型冠状病毒感染、艰难梭菌感染腹泻的认识,对该患者发病原因及诊治进行了探讨。

Clostridium difficile is an anaerobic gram-positive bacterium that forms spores.Over the past decade,the frequency and severity of Clostridium difficile infections have been increasing globally and have become one of the most common hospital-acquired infections.Its clinical manifestations vary from asymptomatic carrier status to varying degrees of diarrhea,and then to the most serious of life-threatening colitis.Here we report the diagnosis and treatment of Clostridium difficile infection in an elderly patient after antibiotic treatment of COVID-19 in a short period of time.Combined with the understanding of diarrhea infected by COVID-19 and Clostridium difficile,the pathogenesis,diagnosis and treatment of the patient were discussed.