血清S100A12、MPO水平对重型颅脑损伤患者发生急性创伤性凝血病的预测价值

Predictive Value of Serum S100A12 and MPO Levels for Occurrence of Acute Traumatic Coagulopathy in Patients with Severe Craniocerebral Injury

目的探讨血清S100钙结合蛋白A12(S100A12)、髓过氧化物酶(MPO)水平对重型颅脑损伤(STBI)患者发生急性创伤性凝血病(ATC)的预测价值。方法选取2019年3月—2022年3月收治的STBI 112例作为研究组,另外选取同期体检健康者120例作为对照组。应用酶联免疫吸附试验测定血清S100A12、MPO水平。根据STBI患者是否发生ATC分为ATC组(n=27)与非ATC组(n=85)。采用受试者工作特征(ROC)曲线评估血清S100A12、MPO对STBI患者发生ATC的预测价值,采用多因素Logistic逐步回归分析探讨STBI患者发生ATC的危险因素。结果研究组血清S100A12、MPO水平高于对照组(P<0.01)。ATC组血清S100A12、MPO水平均高于非ATC组(P<0.01)。血清S100A12、MPO联合预测STBI患者发生ATC的曲线下面积大于二者单独预测。格拉斯哥昏迷量表评分≤3.5分、S100A12≥32.46 ng/mL、MPO≥2.05 ng/mL是STBI患者发生ATC的独立危险因素(P<0.05,P<0.01)。结论血清S100A12、MPO水平升高与STBI患者发生ATC密切相关,其可作为STBI患者是否发生ATC的预测指标,且二者联合预测的效能更高。

Objective To investigate the predictive value of serum S100 calc-binding protein A12(S100A12)and myeloperoxidase(MPO)levels for acute traumatic coagulopathy(ATC)in patients with severe craniocerebral injury(STBI).Methods A total of 112 patients with STBI admitted from March 2019 to March 2022 were selected,and 120 healthy subjects undergoing physical examination during the same period were selected as control group.Serum S100A12 and MPO levels were determined by enzyme-linked immunosorbent assay.Patients with STBI were divided into ATC group(n=27)and non-ATC group(n=85)according to occurrence of ATC.Receiver operating characteristic(ROC)curve was used to evaluate the predictive value of serum S100A12 and MPO for the occurrence of ATC in patients with STBI.Multivariate Logistic stepwise regression analysis was used to explore the risk factors of the occurrence of ATC in patients with STBI.Results Serum S100A12 and MPO water in the research group were higher than those in the control group(P<0.01),and the levels of serum S100A12 and MPO in ATC group were higher than those in non-ATC group(P<0.01).The area under ROC curve(AUC)of the combination of serum S100A12 and MPO for predicting ATC in STBI patients was larger than that predicted by the two indicators alone.Glasgow coma scale score≤3.5 scores,S100A12≥32.46 ng/mL,and MPO≥2.05 ng/mL were independent risk factors for ATC in STBI patients(P<0.05,P<0.01).Conclusion The increase of serum S100A12 and MPO levels is closely related to the occurrence of ATC in STBI patients,which can be used as a predictor of the occurrence of ATC in STBI patients,and the combined prediction efficiency is higher.